Poorolajal Jalal, Shadi Yahya, Heshmati Bahram
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
J Viral Hepat. 2025 Jan;32(1):e14042. doi: 10.1111/jvh.14042.
The objective of this report is to provide clarification on the interaction among hepatitis B virus (HBV), hepatitis C virus (HCV) and alcohol in the development of hepatocellular carcinoma (HCC). A systematic search was performed in PubMed, Web of Science and Scopus databases up to July 18, 2023. The inclusion criteria involved observational studies that examined the relationship between HBV, HCV, alcohol use and the development of HCC. To assess between-study heterogeneity, the I statistics were employed. Publication bias was evaluated using the Begg and Egger tests. The effect sizes were estimated as odds ratios (ORs) with 95% confidence intervals (CIs) utilising a random-effects model. Among the initial pool of 31,021 studies identified, 28 studies involving 42,406 participants met the inclusion criteria. Through our meta-analysis, we found that the combined effect of HBV and alcohol was associated with an OR of 14.56 (95% CI: 9.80, 21.65). The combined impact of HCV and alcohol showed an OR of 42.44 (95% CI: 20.11, 89.56). Coinfection with both HBV and HCV was associated with an OR of 32.58 (95% CI: 20.57, 51.60). These results emphasising the importance of reducing alcohol consumption and implementing effective viral hepatitis prevention and treatment.
本报告的目的是阐明乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和酒精在肝细胞癌（HCC）发生发展中的相互作用。截至2023年7月18日，在PubMed、科学网和Scopus数据库中进行了系统检索。纳入标准包括检查HBV、HCV、酒精使用与HCC发生之间关系的观察性研究。为评估研究间的异质性，采用了I统计量。使用Begg和Egger检验评估发表偏倚。效应大小以比值比（OR）估计，并采用随机效应模型计算95%置信区间（CI）。在最初识别出的31,021项研究中，28项涉及42,406名参与者的研究符合纳入标准。通过我们的荟萃分析，我们发现HBV和酒精的联合效应与OR为14.56（95%CI：9.80，21.65）相关。HCV和酒精的联合影响显示OR为42.44（95%CI：20.11，89.56）。HBV和HCV合并感染与OR为32.58（95%CI：20.57，51.60）相关。这些结果强调了减少酒精消费以及实施有效的病毒性肝炎预防和治疗的重要性。
