Yang Kai, Zhang Ping, Li Jixin, Zhang Genming, Chang Xing
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
J Pharm Anal. 2024 Nov;14(11):101034. doi: 10.1016/j.jpha.2024.101034. Epub 2024 Jul 2.
Myocardial injury (MI) is a common occurrence in clinical practice caused by various factors such as ischemia, hypoxia, infection, metabolic abnormalities, and inflammation. Such damages are characterized by a reduction in myocardial function and cardiomyocyte death that can result in dangerous outcomes such as cardiac failure and arrhythmias. An endoplasmic reticulum stress (ERS)-induced unfolded protein response (UPR) is triggered by several stressors, and its intricate signaling networks are instrumental in both cell survival and death. Cardiac damage frequently triggers ERS in response to different types of injuries and stress. High levels of ERS can exacerbate myocardial damage by inducing necrosis and apoptosis. To target ERS in MI prevention and treatment, current medical research is focused on identifying effective therapy approaches. Traditional Chinese medicine (TCM) is frequently used because of its vast range of applications and low risk of adverse effects. Various studies have demonstrated that active components of Chinese medicines, including polyphenols, saponins, and alkaloids, can reduce myocardial cell death, inflammation, and modify the ERS pathway, thus preventing and mitigating cardiac injury. Thus, this paper aims to provide a new direction and scientific basis for targeting ERS in MI prevention and treatment. We specifically summarize recent research progress on the regulation mechanism of ERS in MI by active ingredients of TCM.
心肌损伤（MI）在临床实践中很常见，由多种因素引起，如缺血、缺氧、感染、代谢异常和炎症。此类损伤的特征是心肌功能下降和心肌细胞死亡，可导致心力衰竭和心律失常等危险后果。几种应激源可引发内质网应激（ERS）诱导的未折叠蛋白反应（UPR），其复杂的信号网络在细胞存活和死亡中都起作用。心脏损伤经常会因不同类型的损伤和应激而引发ERS。高水平的ERS可通过诱导坏死和凋亡加剧心肌损伤。为了在心肌梗死的预防和治疗中靶向ERS，当前医学研究集中在确定有效的治疗方法上。中药（TCM）因其广泛的应用范围和低不良反应风险而经常被使用。各种研究表明，中药的活性成分，包括多酚、皂苷和生物碱，可减少心肌细胞死亡、炎症，并调节ERS途径，从而预防和减轻心脏损伤。因此，本文旨在为在心肌梗死的预防和治疗中靶向ERS提供新的方向和科学依据。我们特别总结了中药活性成分对心肌梗死中ERS调控机制的最新研究进展。
