Shi Linfeng, Ou Lan, Ou Peiling, Deng Lihua, Huang Yonghua, Wang Xingang, Gui Li, Wang Bijia, Dai Limeng, Ma Guolin, Wang Jian, Liu Chen
7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Department of Neurology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
CNS Neurosci Ther. 2024 Dec;30(12):e70171. doi: 10.1111/cns.70171.
The aim of this study was to investigate the whole-brain asymmetry changes in spinocerebellar ataxia type 3 (SCA3) and their association with movement disorders.
Voxel-based morphometry (VBM) was used to assess asymmetry in gray matter (GM) volume in 83 genetically confirmed SCA3 patients and 83 sex- and age-matched healthy controls (HCs). The asymmetry index (AI) was analyzed for partial correlation with disease severity, as measured by the Scale for Assessment and Rating of Ataxia (SARA) and International Cooperative Ataxia Rating Scale (ICARS). Age, sex, and total intracranial volume (TIV) were included as covariates in the analysis.
Asymmetry in GM analysis with SCA3 patients showed decreased leftward asymmetry in cerebellar lobules VIII and IX, the visual cortex, and the putamen, as well as decreased rightward asymmetry in the ventral lateral thalamus, as analyzed by VBM. The AI in the cerebellum, the visual cortex, and the putamen was positively correlated with SARA and ICARS scores, whereas the AI in the thalamus was negatively correlated with these scales.
SCA3 patients exhibit distinct patterns of asymmetrical changes in GM volume, which correlates with motor dysfunction. These changes in asymmetry may serve as potential biomarkers for early intervention in SCA3.
Chinese Clinical Trial Registry (ChiCTR): 1800019901, 2000039434.
本研究旨在调查3型脊髓小脑共济失调（SCA3）患者全脑不对称性变化及其与运动障碍的关联。
采用基于体素的形态学测量（VBM）评估83例基因确诊的SCA3患者和83例性别及年龄匹配的健康对照（HC）的灰质（GM）体积不对称性。分析不对称指数（AI）与疾病严重程度的偏相关性，疾病严重程度通过共济失调评估与评分量表（SARA）和国际合作共济失调评定量表（ICARS）进行测量。分析中纳入年龄、性别和总颅内体积（TIV）作为协变量。
VBM分析显示，SCA3患者GM分析中的不对称性表现为小脑小叶VIII和IX、视觉皮层及壳核的向左不对称性降低，以及腹外侧丘脑的向右不对称性降低。小脑、视觉皮层和壳核中的AI与SARA和ICARS评分呈正相关，而丘脑中的AI与这些量表呈负相关。
SCA3患者在GM体积上表现出独特的不对称变化模式，这与运动功能障碍相关。这些不对称性变化可能作为SCA3早期干预的潜在生物标志物。
中国临床试验注册中心（ChiCTR）：1800019901，2000039434。
