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病例报告:一名子宫内膜癌患者在接受保守治疗后,经受精和胚胎移植成功分娩。

Case report: A successful live birth after fertilization and embryo transfer in a patient with endometrial cancer who was treated conservatively.

作者信息

Fan Yifan, Song Hui, Chen Xu, Zhang Pei, Si Jingwen, Dong Hui

机构信息

Department of Obstetrics and Gynecology, School of Medicine, Nankai University, Tianjin, China.

Department of Obstetrics, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, China.

出版信息

Front Oncol. 2024 Dec 11;14:1461216. doi: 10.3389/fonc.2024.1461216. eCollection 2024.

Abstract

OBJECTIVE

To describe a patient conceiving with fertilization and embryo transfer(IVF-ET) after conservative treatment of early stage endometrial cancer.

PATIENT

A 31-year-old multiparous woman diagnosed with highly-differentiated (G1) endometrial adenocarcinoma (grade IA).

INTERVENTIONS

After four courses of conservative treatment each followed by hysteroscopic biopsy and endometrial curettage,assisted reproductive technology was performed.

MAIN OUTCOME MEASURES

Successful pregnancy and delivery without residual endometrial cancer.

RESULTSS

A healthy normal female infant with a birth weight of 3,690 g was born by cesarean section at 38 + 2 weeks' gestation. No residual malignant cells was detected on a biopsy during cesarean section.

CONCLUSIONS

Conservative fertility-sparing treatment are crucial for young patients with early stage endometrial cancer. Assisted reproductive technologies may be considered to assist such patients to conceive as soon as possible.

摘要

目的

描述1例早期子宫内膜癌经保守治疗后通过体外受精-胚胎移植(IVF-ET)受孕的患者。

患者

一名31岁经产妇,诊断为高分化(G1)子宫内膜腺癌(IA期)。

干预措施

在进行了四个疗程的保守治疗,每个疗程后均进行宫腔镜活检和子宫内膜刮除术后,实施辅助生殖技术。

主要观察指标

成功妊娠并分娩,且无残留子宫内膜癌。

结果

在妊娠38+2周时剖宫产分娩出一名健康正常的女婴,出生体重3690g。剖宫产时活检未检测到残留恶性细胞。

结论

对于早期子宫内膜癌的年轻患者,保留生育功能的保守治疗至关重要。可考虑采用辅助生殖技术帮助此类患者尽快受孕。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ce/11669042/a0bc331dd153/fonc-14-1461216-g001.jpg

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