两天的饥饿不会改变大鼠脑中血脑屏障转运和葡萄糖磷酸化的动力学。

Two-day starvation does not alter the kinetics of blood--brain barrier transport and phosphorylation of glucose in rat brain.

作者信息

Crane P D, Pardridge W M, Braun L D, Oldendorf W H

出版信息

J Cereb Blood Flow Metab. 1985 Mar;5(1):40-6. doi: 10.1038/jcbfm.1985.6.

DOI:10.1038/jcbfm.1985.6

Abstract

The blood-brain barrier (BBB) transport and brain phosphorylation of glucose were assessed in conscious rats subjected to 2 days of starvation. Although plasma glucose decreased, no significant changes in brain blood flow, BBB glucose transport, or 2-deoxy-D-glucose phosphorylation were observed. The data suggest that adaptive changes of brain glucose metabolism previously observed in starvation are located beyond the initial steps of brain entry and phosphorylation.

摘要

在饥饿2天的清醒大鼠中评估了血脑屏障（BBB）对葡萄糖的转运及脑内葡萄糖的磷酸化。尽管血浆葡萄糖水平下降，但未观察到脑血流量、BBB葡萄糖转运或2-脱氧-D-葡萄糖磷酸化有显著变化。这些数据表明，先前在饥饿状态下观察到的脑葡萄糖代谢的适应性变化并非发生在脑摄取和磷酸化的初始步骤。