Hasbek Mürşit, Aldemir Özlem, Çakır Kıymaz Yasemin, Baysal Cihad, Yıldırım Dilara, Büyüktuna Seyit Ali
Department of Medical Microbiology, Sivas Cumhuriyet University Faculty of Medicine,Sivas, Turkey.
Infectious Diseases and Clinical Microbiology Clinic, Ministry of Health, Sivas Numune Hospital, Sivas, Turkey.
Diagn Microbiol Infect Dis. 2025 Mar;111(3):116664. doi: 10.1016/j.diagmicrobio.2024.116664. Epub 2024 Dec 21.
This study aims to evaluate the risk factors associated with the mortality of S. maltophilia infections. Patients aged 18 years and older with S. maltophilia infection. Patients were divided into two groups primary bacteraemia and pneumonia. Of 176 S. maltophilia infections, 85 (48.2 %) were classified as bacteremia and 91 (51.8 %) as pneumonia. The mortality rate was 56 %, with no significant difference observed between the groups. Invasive mechanical ventilation, history of carbapenem use, and high Charlson Comorbidity Index (CCI) were significantly higher in the pneumonia group. In univariate analysis, higher Acute Physiology and Chronic Health Evaluation (APACHE) II score, higher Sequential Organ Failure Assessment (SOFA) score, and use of total parenteral nutrition (TPN) were identified as independent risk factors for 28-day mortality. This study demonstrates a mortality rate of 56 % in S. maltophilia infections and provides concrete data on risk factors for mortality.
本研究旨在评估与嗜麦芽窄食单胞菌感染死亡率相关的危险因素。纳入年龄≥18岁的嗜麦芽窄食单胞菌感染患者。患者分为两组，即原发性菌血症组和肺炎组。在176例嗜麦芽窄食单胞菌感染中，85例（48.2%）被分类为菌血症，91例（51.8%）为肺炎。死亡率为56%，两组之间未观察到显著差异。肺炎组的有创机械通气、碳青霉烯类药物使用史和高查尔森合并症指数（CCI）显著更高。在单因素分析中，较高的急性生理与慢性健康状况评分系统（APACHE）II评分、较高的序贯器官衰竭评估（SOFA）评分以及全胃肠外营养（TPN）的使用被确定为28天死亡率的独立危险因素。本研究显示嗜麦芽窄食单胞菌感染的死亡率为56%，并提供了关于死亡危险因素的确切数据。
