Pasquini Luca, Napolitano Antonio, Spitoni Leonardo, Schmid Maurizio, Dellepiane Francesco, Jenabi Mehrnaz, Peck Kyung, Holodny Andrei
From the Neuroradiology Service (L.P.), Radiology Department, Yale New Haven Hospital, Yale Medical School, New Haven, Connecticut
Neuroradiology Service (L.P., M.J., A.H.), Radiology Department, Memorial Sloan Kettering Cancer Center, New York, New York.
AJNR Am J Neuroradiol. 2025 Jun 3;46(6):1238-1248. doi: 10.3174/ajnr.A8638.
The interaction between language and other cognitive networks in patients harboring brain tumors is poorly understood. We studied the modification of the cognitive control network (CCN) induced by brain tumors and its participation in language reorganization. We hypothesized that patients with brain tumors and reorganized language would show a modification of the CCN compared with patients who remain left dominant.
Patients were selected with the criteria: newly diagnosed, pathologically-confirmed left-hemispheric tumor; single lesions; right-handedness; task-based and resting-state fMRI; no artifacts. Age-matched healthy controls (HC) were recruited from open-source databases. Language laterality was calculated by using task-based fMRI. We obtained the CCN through ad hoc independent component analysis on resting-state fMRI. Differences in CCN between patients and HC were characterized by cosine similarity (CS) and earth mover's distance (EMD). Changes related to language reorganization and patients' speech were assessed with the test ( < .05). Results were corrected for multiple comparisons.
One hundred forty-two right-handed patients (35 low-grade and 88 high-grade gliomas; 19 metastases) and 184 HC were included. Two independent components of the CCN were obtained. The test confirmed significant effects of lateralization on the CCN ( = .004). Modification of CCN was associated with fewer speech deficits 1 week after surgery ( = .005).
This study provides evidence that modifications of CCN occur in the setting of language reorganization. Patients exhibiting these modifications perform better at speech evaluation after surgery, suggesting a role of cognitive control in compensating for speech deficits when language reorganizes.
脑肿瘤患者语言与其他认知网络之间的相互作用尚不清楚。我们研究了脑肿瘤引起的认知控制网络（CCN）的改变及其在语言重组中的作用。我们假设，与保持左侧优势的患者相比，脑肿瘤且语言重组的患者会出现CCN的改变。
选择符合以下标准的患者：新诊断、经病理证实的左侧半球肿瘤；单发病变；右利手；基于任务和静息态功能磁共振成像（fMRI）；无伪影。从开源数据库招募年龄匹配的健康对照（HC）。使用基于任务的fMRI计算语言偏侧性。我们通过对静息态fMRI进行专门的独立成分分析获得CCN。患者与HC之间CCN的差异通过余弦相似度（CS）和推土机距离（EMD）来表征。用检验评估与语言重组和患者言语相关的变化（<0.05）。结果进行了多重比较校正。
纳入142例右利手患者（35例低级别胶质瘤和88例高级别胶质瘤；19例转移瘤）和184例HC。获得了CCN的两个独立成分。检验证实偏侧性对CCN有显著影响（=0.004）。CCN的改变与术后1周较少的言语缺陷相关（=0.005）。
本研究提供了证据表明在语言重组的情况下CCN会发生改变。表现出这些改变的患者术后言语评估表现更好，表明认知控制在语言重组时补偿言语缺陷中发挥作用。
