车前草降低菊粉产气的作用模式及其与结肠微生物群的相互作用：一项针对健康人类志愿者的24小时随机安慰剂对照试验。
Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.
作者信息
Alhasani Alaa T, Modasia Amisha A, Anodiyil Mohamed, Corsetti Maura, Aliyu Abdulsalam I, Crooks Colin, Marciani Luca, Reid Joshua, Yakubov Gleb E, Taylor Moira, Avery Amanda, Harris Hannah, Warren Frederick J, Spiller Robin C
机构信息
Nottingham NIHR Biomedical Research Centre and Nottingham Digestive Disease Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Faculty of Health and Rehabilitation Sciences, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia.
Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
出版信息
J Nutr. 2025 Mar;155(3):839-848. doi: 10.1016/j.tjnut.2024.12.017. Epub 2024 Dec 26.
BACKGROUND
Recent studies show that the increase in breath hydrogen (BH) and symptoms after ingestion of inulin are reduced by coadministering psyllium (PI).
OBJECTIVES
To determine if slowing delivery of inulin to the colon by administering it in divided doses would mimic the effect of PI. Primary endpoint was the BH area under the curve AUC. Secondary endpoints included BH AUC. Exploratory endpoints included the correlation of BH AUC with dietary fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) intake and in vitro fermentation results.
METHODS
A total of 17 healthy adults were randomly assigned to a single-blind, 3-arm, crossover trial. All consumed 20 g inulin (I) powder dissolved in 500 mL water and mixed with either 20 g maltodextrin (control) or 20 g PI consumed as a single dose or 20 g inulin given in divided doses (DDI), 62.5 mL every 45 min over 6 h. Twenty-four-hour BH, dietary FODMAP intake, stool microbiota, and gas production in vitro were measured. Responders were defined as those whose AUC BH was reduced by PI, whereas nonresponders showed no reduction.
RESULTS
Compared with control, PI did not reduce mean BH AUC, whereas DDI increased it, P < 0.0002. DDI and PI both significantly reduced BH AUC compared with the control, P < 0.0001. However, subsequently, DDI significantly increased BH from 6 to 12 h (P < 0.0001) and overnight (12-24 h) (P < 0.0001), whereas PI did so only overnight (P = 0.0002). Nonresponders showed greater release of arabinose during in vitro fermentation and higher abundance of 2 species, Clostridium spp. AM22_11AC and Phocaeicola dorei, which also correlated with BH production on PI. Dietary FODMAP intake tended to correlate inversely with BH AUC (r = -0.42, P = 0.09) and correlated with microbiome community composition.
CONCLUSIONS
DDI, like PI, reduces early BH production. PI acts by delaying transit to the colon but not reducing colonic fermentation over 24 h. Dietary FODMAP intake correlates with BH response to inulin and the microbiome. This trial was registered at www.
CLINICALTRIALS
gov as NCT05619341.
背景
近期研究表明，同时服用车前子壳（PI）可降低摄入菊粉后呼气氢气（BH）的增加及相关症状。
目的
确定通过分剂量服用菊粉来减缓其向结肠的递送是否会模拟PI的效果。主要终点是BH曲线下面积（AUC）。次要终点包括BH AUC。探索性终点包括BH AUC与膳食可发酵寡糖、双糖、单糖和多元醇（FODMAPs）摄入量以及体外发酵结果的相关性。
方法
共有17名健康成年人被随机分配到一项单盲、三臂、交叉试验中。所有人均服用溶解于500 mL水中并与20 g麦芽糊精（对照）或20 g PI混合的20 g菊粉（I）粉末，PI或为单次服用，或为分剂量服用（DDI，6小时内每45分钟服用62.5 mL）。测量24小时的BH、膳食FODMAP摄入量、粪便微生物群和体外产气情况。反应者定义为AUC BH因PI而降低的人，而非反应者则未出现降低。
结果
与对照组相比，PI未降低平均BH AUC，而DDI使其增加，P < 0.0002。与对照组相比，DDI和PI均显著降低了BH AUC，P < 0.0001。然而，随后，DDI在6至12小时（P < 0.0001）和过夜（12 - 24小时）（P < 0.0001）显著增加了BH，而PI仅在过夜时增加（P = 0.0002）。非反应者在体外发酵过程中阿拉伯糖释放量更高，且两种菌种（梭菌属AM22_11AC和多雷菲卡埃icola）丰度更高，这也与服用PI时的BH产生相关。膳食FODMAP摄入量与BH AUC呈负相关趋势（r = -0.42，P = 0.09），并与微生物群落组成相关。
结论
DDI与PI一样，可降低早期BH的产生。PI通过延迟转运至结肠起作用，但在24小时内不会减少结肠发酵。膳食FODMAP摄入量与对菊粉的BH反应及微生物群相关。该试验已在www.CLINICALTRIALS.gov上注册，注册号为NCT05619341。
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