Yasuda Y, Kasahara K, Tenmoku S, Yabe C, Miyata M, Morioka Y, Sakamoto Y, Kuzuya T, Takeda K, Atsumi T, Shimizu H, Matsumoto S
Jpn J Surg. 1979 Dec;9(4):350-8. doi: 10.1007/BF02468636.
A 34-year-old woman had episodes of hypoglycemic attack 8 years after a surgical resection of a retroperitoneal hemangiopericytoma. In spite of normal levels of serum IRI, insulin radioreceptor assay demonstrated high level of plasma ILA (insulin like activity). The patient underwent resection of a recurrent retroperitoneal tumor with metastatic lesions of the liver. Postoperatively, ILA level in plasma by insulin radioreceptor assay decreased, and hypoglycemic attacks disappeared. Therefore, this associated hypoglycemia was presumed to be not caused by excess glucose consumption by the tumor, not by excess secretion of IRI by the tumor, but caused by the presence of high level of ILA related to the tumor.
一名34岁女性在腹膜后血管外皮细胞瘤手术切除8年后出现低血糖发作。尽管血清胰岛素免疫反应性(IRI)水平正常,但胰岛素放射受体测定显示血浆ILA(胰岛素样活性)水平升高。该患者接受了复发性腹膜后肿瘤伴肝转移灶的切除术。术后,通过胰岛素放射受体测定的血浆ILA水平下降,低血糖发作消失。因此,推测这种伴发性低血糖不是由肿瘤过度消耗葡萄糖引起的,也不是由肿瘤过度分泌IRI引起的,而是由与肿瘤相关的高水平ILA的存在引起的。