Stern J E, Wira C R
J Reprod Immunol. 1985 Jan;7(1):77-87. doi: 10.1016/0165-0378(85)90022-1.
Secretory component (SC) was measured in amniotic fluid, fetal serum, and maternal serum and compared with SC production during in vitro culture of uterine tissue segments from pregnant rats. The concentrations of SC in amniotic fluid did not change between days 14 and 20 of pregnancy. Similarly, there was no change in maternal or fetal serum during pregnancy, although, the levels of SC in sera were consistently higher than those in amniotic fluid. When uterine segments were incubated in vitro, release of SC was greater in the absence of cycloheximide than in the presence of cycloheximide at all stages of pregnancy. In contrast to SC values in amniotic fluid, however, SC production by uterine tissue changed markedly during pregnancy. SC levels were low during early pregnancy (day 7 post coitus) and increased to levels found in non-pregnant diestrous rats just prior to parturition (day 20). The findings suggest that the endocrine balance during pregnancy may play a central role in regulation of the uterus immune system. The pattern of SC release may reflect a need both to ensure protection of the fetus from the IgA immune system in early pregnancy and to prevent maternal infection during parturition by reactivation of this system.
在羊水、胎儿血清和母体血清中检测分泌成分（SC），并将其与妊娠大鼠子宫组织片段体外培养期间的SC产生情况进行比较。妊娠第14天至20天期间，羊水中SC的浓度没有变化。同样，妊娠期间母体或胎儿血清中也没有变化，不过，血清中SC的水平始终高于羊水中的水平。当子宫片段进行体外培养时，在妊娠的所有阶段，无环己酰亚胺时SC的释放量都比有环己酰亚胺时更大。然而，与羊水中的SC值不同，子宫组织产生的SC在妊娠期间有明显变化。妊娠早期（交配后第7天）SC水平较低，在分娩前（第20天）升高至非妊娠动情间期大鼠的水平。这些发现表明，妊娠期间的内分泌平衡可能在子宫免疫系统的调节中起核心作用。SC释放模式可能既反映了在妊娠早期确保胎儿免受IgA免疫系统影响的需求，也反映了通过激活该系统来预防分娩期间母体感染的需求。
