Byington R P, Curb J D, Mattson M E
JAMA. 1985;253(12):1733-6.
At the conclusion of a double-blinded, randomized clinical trial of propranolol hydrochloride, but before unblinding, the patients and clinic personnel were asked to guess the treatment group assignment of each patient. While 79.9% of the patients receiving propranolol correctly identified their treatment group assignment, 57.2% of the patients receiving placebo incorrectly guessed that they were also in the propranolol group. No specific mechanism was identified to explain why more patients receiving propranolol were better able to guess their group assignment. Clinic physicians correctly identified the group assignment of 69.9% of the patients receiving propranolol and 68.8% of the patients receiving placebo. Clinic coordinators correctly identified the group assignment of 67.1% of the patients receiving propranolol and 70.6% of the patients receiving placebo. For clinic personnel, heart rate level and heart rate change seem to be the mechanisms employed to identify their patients' treatment assignment.
在一项盐酸普萘洛尔双盲随机临床试验结束时，但在揭盲之前，要求患者和临床工作人员猜测每位患者的治疗组分配情况。接受普萘洛尔治疗的患者中有79.9%正确识别了自己的治疗组分配情况，而接受安慰剂治疗的患者中有57.2%错误地猜测自己也在普萘洛尔组。未发现具体机制来解释为什么更多接受普萘洛尔治疗的患者更能猜出自己的组分配情况。临床医生正确识别了接受普萘洛尔治疗的患者中的69.9%以及接受安慰剂治疗的患者中的68.8%的组分配情况。临床协调员正确识别了接受普萘洛尔治疗的患者中的67.1%以及接受安慰剂治疗的患者中的70.6%的组分配情况。对于临床工作人员而言，心率水平和心率变化似乎是他们识别患者治疗分配情况所采用的机制。
