Lee Daniel, Emblin Kate, Daniels Rob, Kallis Tomazo Joseph, Alallan Mohammad, Mokbel Kinan
Department of Health and Care Professions, Faculty of Health and Life Sciences, University of Exeter, Exeter, U.K.
Royal Devon University NHS Foundation Trust, Exeter, U.K.
In Vivo. 2025 Jan-Feb;39(1):566-571. doi: 10.21873/invivo.13861.
BACKGROUND/AIM: Transient ischaemic attack (TIA) is characterised by a temporary neurological dysfunction resulting from focal ischaemia in the brain, spinal cord or retina without acute infarction. These episodes typically last less than 24 hours and are significant predictors of subsequent ischaemic strokes. Hypertension is a major risk factor for cerebrovascular events, and primary aldosteronism (PA) is recognised as a common cause of secondary hypertension. This case report presents a male patient with secondary hypertension due to Conn Syndrome, a form of PA, who experienced a TIA manifesting as left leg weakness, underscoring the heightened stroke risk associated with secondary hypertension.
A 78-year-old male with secondary hypertension caused by Conn Syndrome presented with an episode of left leg weakness that resolved within 24 hours. After ruling out other potential causes such as metabolic disturbances, infections, and structural brain lesions, he was diagnosed with TIA and treated with dual antiplatelet therapy. A carotid ultrasound revealed significant stenosis, leading to a referral for carotid endarterectomy. Long-term management included clopidogrel monotherapy and optimising hypertension control.
This case highlights the increased stroke risk in patients with Conn Syndrome-related hypertension, emphasising the importance of early recognition and optimising hypertension management in patients with secondary hypertension to prevent future cerebrovascular events.
背景/目的：短暂性脑缺血发作（TIA）的特征是由大脑、脊髓或视网膜局灶性缺血引起的短暂性神经功能障碍，而无急性梗死。这些发作通常持续少于24小时，是随后缺血性卒中的重要预测指标。高血压是脑血管事件的主要危险因素，原发性醛固酮增多症（PA）被认为是继发性高血压的常见原因。本病例报告介绍了一名因Conn综合征（一种PA形式）导致继发性高血压的男性患者，该患者经历了一次表现为左腿无力的TIA，强调了继发性高血压相关的中风风险增加。
一名78岁男性因Conn综合征导致继发性高血压，出现一次左腿无力发作，在24小时内缓解。排除其他潜在原因，如代谢紊乱、感染和脑部结构病变后，他被诊断为TIA并接受双重抗血小板治疗。颈动脉超声显示严重狭窄，导致转诊进行颈动脉内膜切除术。长期管理包括氯吡格雷单药治疗和优化高血压控制。
本病例突出了Conn综合征相关高血压患者中风风险增加，强调了早期识别和优化继发性高血压患者高血压管理以预防未来脑血管事件的重要性。
