Hoffrén Joel, Määttä Juhani, Karppinen Jaro, Oura Petteri, Heikkala Eveliina
Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.
Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland; Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.
J Psychosom Res. 2025 Feb;189:112026. doi: 10.1016/j.jpsychores.2024.112026. Epub 2024 Dec 22.
This cross-sectional study demonstrates the differences in the dimensions of musculoskeletal (MSK) pain between participants with mental distress and/or insomnia among general population with MSK pain within the past 12 months.
Participants of Northern Finland Birth Cohort 1966 (NFBC1966) were studied (n = 4316). They were divided into groups based on their mental distress and insomnia status (co-occurring mental distress and insomnia [CMI], isolated mental distress [M] and insomnia [I], and absence of both [AMI]). The AMI group was used as a reference for the main analyses. The dimensions of MSK pain included frequency, bothersomeness (Numerical Rating Scale [NRS] 0-10), intensity of pain (NRS), and number of pain sites (1-8). Multinomial and general linear regression analyses were used to study the associations, and adjustments were made for sex, education, number of somatic diseases, and physical activity.
The CMI group was associated with more severe pain in every dimension when contrasted to all other groups (daily pain adjusted OR 5.08, 95 % CI 3.43-7.51; bothersomeness adjusted β 1.7, 95 % CI 1.5-2.0; intensity adjusted β 1.4, 95 % CI 1.2-1.7; number of pain sites adjusted β 1.2, 95 % CI 1.0-1.4). Compared to AMI, I and M groups also had relationships with all pain dimensions, but with lower magnitude compared to the CMI group.
The results suggest that insomnia and mental distress co-exist with more severe MSK pain, and when co-occurring, MSK pain severity tends to increase. Therefore, contemplating insomnia and mental distress are important to consider when comprehensively evaluating MSK pain symptoms.
这项横断面研究揭示了在过去12个月内患有肌肉骨骼疼痛的普通人群中，存在精神困扰和/或失眠的参与者在肌肉骨骼（MSK）疼痛程度上的差异。
对1966年芬兰北部出生队列（NFBC1966）的参与者进行了研究（n = 4316）。根据他们的精神困扰和失眠状况将他们分为几组（共病精神困扰和失眠[CMI]、孤立性精神困扰[M]和失眠[I]，以及两者皆无[AMI]）。AMI组用作主要分析的参照组。MSK疼痛程度包括频率、困扰程度（数字评定量表[NRS]0 - 10）、疼痛强度（NRS）和疼痛部位数量（1 - 8）。采用多项和一般线性回归分析来研究相关性，并对性别、教育程度、躯体疾病数量和身体活动进行了校正。
与所有其他组相比，CMI组在各个维度上的疼痛都更严重（每日疼痛校正比值比5.08，95%置信区间3.43 - 7.51；困扰程度校正β值1.7，95%置信区间1.5 - 2.0；强度校正β值1.4，9�%置信区间1.2 - 1.7；疼痛部位数量校正β值1.2，95%置信区间1.0 - 1.4）。与AMI组相比，I组和M组也与所有疼痛维度有关，但与CMI组相比程度较低。
结果表明，失眠和精神困扰与更严重的MSK疼痛共存，并且当两者同时出现时，MSK疼痛严重程度往往会增加。因此，在全面评估MSK疼痛症状时，考虑失眠和精神困扰很重要。
