儿童和青少年2型糖尿病的兴起:一场新出现的大流行。

The Rise of Type 2 Diabetes in Children and Adolescents: An Emerging Pandemic.

作者信息

Goyal Shiwali, Vanita Vanita

机构信息

Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.

Department of Human Genetics, Guru Nanak Dev University, Amritsar, India.

出版信息

Diabetes Metab Res Rev. 2025 Jan;41(1):e70029. doi: 10.1002/dmrr.70029.

Abstract

AIM

This review explores the increasing prevalence of Type 2 Diabetes Mellitus (T2DM) in children and adolescents, focusing on its etiology, risk factors, complications, and the importance of early detection and management. It also highlights the need for a multidisciplinary, family-centered approach in managing T2DM in pediatric populations, with an emphasis on nutrition, exercise, and lifestyle interventions.

MATERIALS AND METHODS

A literature review was conducted using PubMed, Google Scholar, and Scopus to incorporate studies from 2015 to 2024 on T2DM in youths/adolescents/children, focusing on epidemiology, risk factors, and prevention strategies. Studies on Type 1 Diabetes Mellitus (T1DM) or adult populations were excluded.

RESULTS

T2DM is a complex metabolic disorder with various societal, behavioral, environmental, and genetic risk factors. It accounts for one in three new childhood diabetes cases, with rising incidence among American Indian/Alaska Native, Black, and Hispanic/Latino children. The increase in T2DM incidence correlates with growing childhood obesity rates. Early onset significantly raises the risk of complications like retinopathy, nephropathy, neuropathy, cardiovascular diseases, nonalcoholic fatty liver disease, and obstructive sleep apnea. Early detection, screening, and treatment can prevent or delay these complications. A family-centered, multidisciplinary approach is essential for effective management, including lifestyle and behavioral support.

CONCLUSIONS

T2DM in children is a growing health concern with severe implications. Early detection and management, including nutrition and exercise counseling, are critical in reducing long-term complications. A multidisciplinary approach is vital for improving outcomes and minimizing morbidity and mortality.

摘要

目的

本综述探讨2型糖尿病(T2DM)在儿童和青少年中的患病率不断上升的情况,重点关注其病因、危险因素、并发症以及早期检测和管理的重要性。它还强调了在儿科人群中管理T2DM时采用多学科、以家庭为中心的方法的必要性,重点是营养、运动和生活方式干预。

材料和方法

使用PubMed、谷歌学术和Scopus进行文献综述,纳入2015年至2024年关于青少年/儿童T2DM的研究,重点是流行病学、危险因素和预防策略。排除1型糖尿病(T1DM)或成人人群的研究。

结果

T2DM是一种复杂的代谢紊乱疾病,具有多种社会、行为、环境和遗传危险因素。它占新诊断儿童糖尿病病例的三分之一,在美国印第安人/阿拉斯加原住民、黑人以及西班牙裔/拉丁裔儿童中的发病率呈上升趋势。T2DM发病率的增加与儿童肥胖率的上升相关。早发显著增加了视网膜病变、肾病、神经病变、心血管疾病、非酒精性脂肪性肝病和阻塞性睡眠呼吸暂停等并发症的风险。早期检测、筛查和治疗可以预防或延迟这些并发症。以家庭为中心的多学科方法对于有效管理至关重要,包括生活方式和行为支持。

结论

儿童T2DM是一个日益严重的健康问题,具有严重影响。早期检测和管理,包括营养和运动咨询,对于减少长期并发症至关重要。多学科方法对于改善结局以及将发病率和死亡率降至最低至关重要。

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