The conversion of bio-based molecules into valuable chemicals is essential for advancing sustainable processes and addressing global resource challenges. However, conventional catalytic methods often demand harsh conditions and suffer from low product selectivity. This study introduces a series of bifunctional PdPt catalysts supported on TiO, designed for achieving selective and mild-temperature catalysis in biomass conversion. Synthesized via a sol immobilization method and characterized by XRF, N physisorption, HRTEM, HAADF-STEM, and XPS, these catalysts demonstrate superior selectivity and activity over monometallic counterparts. In fact, at 20 bar H, Pt/TiO show a low selectivity in benzophenone hydrodeoxygenation, favoring the benzhydrol hydrogenation product; similarly, Pd/TiO preferentially form the diphenylmethane hydrodeoxygenation (HDO) product, but with slow conversion rates. The synergistic combination of the two metals in PdPt/TiO drastically improve performance, with 100 % benzophenone conversion and 73 % diphenylmethane selectivity. DFT calculations confirm the synergy between Pd and Pt as the key to drive the activity and selectivity. Additionally, the catalysts also demonstrate high recyclability with minimal performance loss, and have been generalized for the HDO of vanillin and furfural, and in HMF oxidation. Overall, this work highlights the potential of bimetallic catalysts in enabling efficient and selective bio-based molecule conversion under mild conditions.