诱变化合物咪唑并[4,5-f]喹啉和喹喔啉（IQ化合物）的分析。电化学检测与紫外检测的比较。
Analysis of mutagenic imidazo[4,5-f]quinolines and -quinoxalines (IQ compounds). Comparison of electrochemical and ultraviolet detection.
作者信息
Grivas S, Nyhammar T
出版信息
Mutat Res. 1985 Jan-Feb;142(1-2):5-8. doi: 10.1016/s0165-7992(85)80003-8.
PMID:3974600
Abstract
Two synthetic imidazoquinolin-2-amines (IQ and MeIQ) and two imidazoquinoxalin-2-amines (MeIQx and 4,8-DiMeIQx), all known potent mutagens, have been separated by reversed-phase HPLC and detected by two methods - UV detection and electrochemical (EC) detection. The limits of detection were found to be 2.5 pmoles for UV detection and 0.5-1.5 pmoles for electrochemical detection.
摘要
两种合成的咪唑并喹啉 - 2 - 胺（IQ和MeIQ）以及两种咪唑并喹喔啉 - 2 - 胺（MeIQx和4,8 - 二甲基咪唑并喹喔啉），均为已知的强诱变剂，已通过反相高效液相色谱法分离，并采用紫外检测和电化学（EC）检测两种方法进行检测。结果发现，紫外检测的检测限为2.5皮摩尔，电化学检测的检测限为0.5 - 1.5皮摩尔。
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