Song Kyungchul, Seol Eun Gyung, Lee Eunju, Lee Hye Sun, Lee Hana, Chae Hyun Wook, Shin Hyun Joo
Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
Gut Liver. 2025 Jan 15;19(1):108-115. doi: 10.5009/gnl240342. Epub 2025 Jan 3.
BACKGROUND/AIMS: To evaluate the associations between pediatric fatty liver severity, bioelectrical impedance analysis (BIA), and magnetic resonance imaging parameters, including total psoas muscle surface area (tPMSA) and paraspinal muscle fat (PMF).
Children and adolescents who underwent BIA and liver magnetic resonance imaging between September 2022 and November 2023 were included. Linear regression analyses identified predictors of liver proton density fat fraction (PDFF) including BIA parameters, tPMSA, and PMF. Ordinal logistic regression analysis identified the association between these parameters and fatty liver grades. Pearson's correlation coefficients were used to evaluate the relationships between tPMSA and muscle-related BIA parameters, and between PMF and fat-related BIA parameters.
Overall, 74 participants aged 8 to 16 years were included in the study. In the linear regression analyses, the percentage of body fat was positively associated with PDFF in all participants, whereas muscle-related BIA parameters were negatively associated with PDFF in participants with obesity. PMF and the PMF index were positively associated with PDFF in normalweight and overweight participants. In the ordinal logistic regression, percentage of body fat was positively associated with fatty liver grade in normal-weight and overweight participants and those with obesity, whereas muscle-related BIA parameters were negatively associated with fatty liver grade in participants with obesity. The PMF index was positively associated with fatty liver grade in normal/overweight participants. In the Pearson correlation analysis, muscle-related BIA parameters were correlated with tPMSA, and the fat-related BIA parameters were correlated with PMF.
BIA parameters and PMF are potential screening tools for assessing fatty liver in children.
背景/目的：评估儿童脂肪肝严重程度、生物电阻抗分析（BIA）与磁共振成像参数之间的关联，这些参数包括腰大肌总表面积（tPMSA）和椎旁肌脂肪（PMF）。
纳入2022年9月至2023年11月期间接受BIA和肝脏磁共振成像检查的儿童和青少年。线性回归分析确定了肝脏质子密度脂肪分数（PDFF）的预测因素，包括BIA参数、tPMSA和PMF。有序逻辑回归分析确定了这些参数与脂肪肝分级之间的关联。使用Pearson相关系数评估tPMSA与肌肉相关BIA参数之间以及PMF与脂肪相关BIA参数之间的关系。
总体而言，74名年龄在8至16岁的参与者纳入了该研究。在线性回归分析中，所有参与者的体脂百分比与PDFF呈正相关，而肥胖参与者中与肌肉相关的BIA参数与PDFF呈负相关。在正常体重和超重参与者中，PMF和PMF指数与PDFF呈正相关。在有序逻辑回归中，正常体重、超重参与者和肥胖参与者的体脂百分比与脂肪肝分级呈正相关，而肥胖参与者中与肌肉相关的BIA参数与脂肪肝分级呈负相关。在正常/超重参与者中，PMF指数与脂肪肝分级呈正相关。在Pearson相关分析中，与肌肉相关的BIA参数与tPMSA相关，与脂肪相关的BIA参数与PMF相关。
BIA参数和PMF是评估儿童脂肪肝的潜在筛查工具。
