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建立永久性腹膜PleurX导管作为恶性腹水的姑息治疗方法。

Establishment of permanent peritoneal PleurX catheter as palliative treatment of malignant ascites.

作者信息

Mortensen Marie Riis, Ngyuen Tue Duy, Madsen Hans Henrik, Meier Michelle

机构信息

Department of Gastrointestinal Surgery, Copenhagen University Hospital - Hvidovre Hospital.

Department of Gastrointestinal Surgery, Aarhus University Hospital.

出版信息

Dan Med J. 2024 Nov 12;71(12):A02240098. doi: 10.61409/A02240098.

Abstract

INTRODUCTION

Refractory malignant ascites (RMA) is a manifestation of end-stage cancer disease with a major impact on quality of life due to the symptom burden and need for repeated hospitalisations. We previously described the implantation of the permanent PleurX catheter as a treatment of RMA. The present study aimed to evaluate and describe our experience with the permanent PleurX catheter system in the largest cohort to date.

METHODS

A total of 97 consecutive patients had a PleurX catheter implanted from 2015 to 2021. We retrieved retrospective data on patients and procedures using the patient's medical records.

RESULTS

A total of 96 (99%) of implantations were successful, and all patients had symptom relief. Six patients (6%) experienced minor or moderate adverse events: three due to infection, two due to leakage and one because of hypotension. The mean residual lifetime was 77 days.

CONCLUSIONS

We established that implantation of the permanent peritoneal PleurX catheter is a safe and efficient treatment of RMA. We emphasise the importance of early detection and intervention in the management of RMA by implantation of a permanent peritoneal catheter.

FUNDING

None.

TRIAL REGISTRATION

Not relevant.

摘要

引言

难治性恶性腹水(RMA)是终末期癌症疾病的一种表现,由于症状负担和需要反复住院,对生活质量有重大影响。我们之前描述了植入永久性PleurX导管作为RMA的一种治疗方法。本研究旨在评估并描述我们在迄今为止最大队列中使用永久性PleurX导管系统的经验。

方法

2015年至2021年期间,共有97例连续患者植入了PleurX导管。我们使用患者的病历检索了有关患者和手术的回顾性数据。

结果

总共96例(99%)植入成功,所有患者症状均得到缓解。6例患者(6%)经历了轻微或中度不良事件:3例因感染,两例因渗漏,1例因低血压。平均剩余生存期为77天。

结论

我们确定,植入永久性腹膜PleurX导管是治疗RMA的一种安全有效的方法。我们强调通过植入永久性腹膜导管在RMA管理中进行早期检测和干预的重要性。

资金来源

无。

试验注册

不相关。

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