Qu Zhengpeng, Pazo Emmanuel Eric, Yang Ling, Chen Jiayan, Qin Guanghao, He Wei
Jinzhou Medical University, Jinzhou, China.
He Eye Specialist Hospital, Shenyang, China.
BMJ Open. 2025 Jan 4;15(1):e087530. doi: 10.1136/bmjopen-2024-087530.
Overexpression of tear matrix metalloproteinases-9 (MMP-9) on the ocular surface tissues has been reported to result in ocular surface damage. MMP-9 levels in tears have been listed as one of many tools for confirming dry eye disease (DED).
This investigation aimed to compare MMP-9 levels and ocular surface parameters in diabetic patients with and without DED.
A cross-sectional study.
He Eye Specialist Hospital, Shenyang, China.
This study recruited 144 right eyes of 144 diabetic patients between November and December of 2023, and 110 patients with similar propensity scores were included in the analyses.
Non-invasive breakup time (NITBUT), tear film lipid layer (TFLL), conjunctival hyperaemia (redness score (RS)), corneoconjunctival staining (CS), corneal sensitivity and Ocular Surface Disease Index (OSDI) questionnaire were evaluated. MMP-9 was measured using an immunochromatography assay.
In total, 55 patients (55 eyes) were grouped as diabetic dry eye (DDE) and 55 patients (55 eyes) as diabetic non-dry eye (DNDE). The mean MMP-9 concentrations were higher in patients with DDE than DNDE (70.63±52.06 ng/mL vs 33.98±33.93 ng/mL; p<0.001). The optimal cut-off value of MMP-9 to predict DED in diabetic patients was>52.5 ng/mL, with 58.2% sensitivity and 78.2% specificity.
MMP-9 concentration was higher in patients with DDE than DNDE. The MMP-9 test is a potential diagnostic tool for DDE. It may help follow-up diabetic patients with DED and guide clinicians in deciding on anti-inflammatory treatments for these patients.
据报道，眼表组织中泪液基质金属蛋白酶-9（MMP-9）的过表达会导致眼表损伤。泪液中的MMP-9水平已被列为确诊干眼症（DED）的众多指标之一。
本研究旨在比较患有和未患有DED的糖尿病患者的MMP-9水平和眼表参数。
一项横断面研究。
中国沈阳何氏眼科医院。
本研究于2023年11月至12月招募了144例糖尿病患者的144只右眼，并纳入了110例倾向评分相似的患者进行分析。
评估非侵入性泪膜破裂时间（NITBUT）、泪膜脂质层（TFLL）、结膜充血（发红评分（RS））、角膜结膜染色（CS）、角膜敏感性和眼表疾病指数（OSDI）问卷。使用免疫层析法测量MMP-9。
总共55例患者（55只眼）被归类为糖尿病性干眼（DDE），55例患者（55只眼）被归类为糖尿病非干眼（DNDE）。DDE患者的平均MMP-9浓度高于DNDE患者（70.63±52.06 ng/mL对33.98±33.93 ng/mL；p<0.001）。预测糖尿病患者DED的MMP-9最佳临界值>52.5 ng/mL，敏感性为58.2%，特异性为78.2%。
DDE患者的MMP-9浓度高于DNDE患者。MMP-9检测是DDE的一种潜在诊断工具。它可能有助于对患有DED的糖尿病患者进行随访，并指导临床医生为这些患者决定抗炎治疗方案。
