Thein David, Maul Julia-Tatjana, Ribero Simone, Silverberg Jonathan I, Egeberg Alexander, Thyssen Jacob P
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Contact Dermatitis. 2025 May;92(5):358-366. doi: 10.1111/cod.14732. Epub 2025 Jan 5.
The epidemiology of chronic hand eczema (CHE) remains poorly examined.
To investigate the prevalence of CHE in a general adult population and describe the characteristics of affected individuals.
We investigated the prevalence and characteristics of CHE using a random sample from the general Danish population (The Danish Skin Cohort). CHE was defined as eczema on the hands or wrists during a minimum of three consecutive months or reoccurrence of hand eczema at least twice within 12 months.
Out of 11 166 adults, 1306 experienced hand eczema (HE) at some point in their lifetime. Within the last 12 months, 408 (3.7%) experienced HE, of which 332 (81.4%) reported CHE. The crude 1-year period prevalence of CHE was 3.0% (95% confidence interval (CI), 2.7%-3.3%) while the standardised prevalence was 3.5% (95% CI, 3.3%-3.6%). Among adults with CHE, 70.8% were female, and the mean age was 48.0 years (standard deviation 16.6 years). Most individuals with CHE had two relapses (n = 309, 93.1%), while n = 206, 61.1%, had HE for more than 3 months. Compared to HE, CHE was more likely diagnosed by a dermatologist and affect the fingers and back of the hand.
The standardised prevalence was 3.5% (95% CI, 3.3%-3.6%) and 4.2% (95% CI, 4.0%-4.4%) for CHE and HE, respectively. We identified a large overlap between HE and CHE (81.4%) in adults from the general population, indicating that many individuals affected by eczema on the hands may experience a chronic course.
慢性手部湿疹（CHE）的流行病学研究仍不充分。
调查普通成年人群中CHE的患病率，并描述受影响个体的特征。
我们使用丹麦普通人群的随机样本（丹麦皮肤队列）调查了CHE的患病率和特征。CHE定义为手部或手腕部湿疹持续至少连续三个月，或手部湿疹在12个月内复发至少两次。
在11166名成年人中，1306人一生中曾患手部湿疹（HE）。在过去12个月内，408人（3.7%）患过HE，其中332人（81.4%）报告患有CHE。CHE的1年粗患病率为3.0%（95%置信区间（CI），2.7%-3.3%），标准化患病率为3.5%（95%CI，3.3%-3.6%）。在患有CHE的成年人中，70.8%为女性，平均年龄为48.0岁（标准差16.6岁）。大多数CHE患者有两次复发（n = 309，93.1%），而n = 206（61.1%）的HE持续时间超过3个月。与HE相比，CHE更有可能由皮肤科医生诊断，且累及手指和手背。
CHE和HE的标准化患病率分别为3.5%（95%CI，3.3%-3.6%）和4.2%（95%CI，4.0%-4.4%）。我们发现普通人群中成年人的HE和CHE有很大重叠（81.4%），这表明许多手部湿疹患者可能经历慢性病程。
