Jiang Lan, Ding Shulong, Wang Juxia
School of Nursing, Anhui Medical University, Hefei, China.
Department of Trauma and Orthopedic Surgery, Huangshan City People's Hospital, Huangshan, Anhui, China.
Aging Male. 2025 Dec;28(1):2442571. doi: 10.1080/13685538.2024.2442571. Epub 2025 Jan 6.
Previous studies have established a correlation between frailty and an increased risk of falls among middle-aged and elderly individuals within community settings. The frailty status of hospitalized and community-dwelling adults aged 60 or older with hip fractures is poorly investigated. This study aims to examine the relationship between frailty status and falls in China among community-dwelling and hospitalized individuals with hip fractures aged 60 and older.
Data from the Huangshan City People's Hospital's Department of Trauma and Orthopedics (a single center), and the China Health and Retirement Longitudinal Study (CHARLS) were used in this investigation. Falls were self-reported, and frailty was measured using the FRAIL scale. The association between frailty and falls was examined using logistic regression models, restricted cubic splines (RCS), and subgroup analysis. Appropriate adjustments were made for confounding factors, such as age, gender, marital status, education level, smoking, drinking, body mass index (BMI), hearing and vision impairment, hypertension, diabetes, medication history, exercise, and hip fracture.
After applying the inclusion and exclusion criteria, 5224 subjects from CHARLS (male: 52.2%, female: 47.8%) and 174 patients from the trauma and orthopedic ward (male: 36.2%, female: 63.8%) were included. Analysis revealed a strong association between each additional point in the frailty score and an increased risk of fall in patients aged 60 and older (CHARLS, OR: 1.53, 95% CI: 1.41-1.66; A single center, OR: 1.57, 95% CI: 0.92-2.71). This association was even more pronounced in the pre-frail (CHARLS, OR: 1.95, 95% CI: 1.65-2.32; A single center, OR: 1.67, 95% CI: 0.46-6.08) and frail (CHARLS, OR: 3.43, 95% CI: 2.51-4.68; A single center, OR: 4.01, 95% CI: 0.61-26.41) groups compared to the control group. Subgroup studies revealed a sex-related interaction between frailty and falls in patients with hip fractures but not in older persons residing in the community. Furthermore, RCS regression revealed a linear correlation between frailty and falls in both groups.
This study found a positive association between frailty status and falls in CHARLS and hip fracture patients from a single center. Gender differences in this relationship were observed only in hip fracture patients. These findings highlight the importance of frailty to community workers and clinical practitioners.
既往研究已证实社区环境中老年个体的衰弱与跌倒风险增加之间存在关联。对于60岁及以上髋部骨折的住院及社区居住成年人的衰弱状况研究较少。本研究旨在探讨中国60岁及以上髋部骨折的社区居住和住院个体的衰弱状况与跌倒之间的关系。
本研究使用了黄山市人民医院创伤骨科(单中心)的数据以及中国健康与养老追踪调查(CHARLS)的数据。跌倒情况通过自我报告获取,衰弱状况使用衰弱量表(FRAIL)进行测量。采用逻辑回归模型、受限立方样条(RCS)和亚组分析来检验衰弱与跌倒之间的关联。对年龄、性别、婚姻状况、教育水平、吸烟、饮酒、体重指数(BMI)、听力和视力障碍、高血压、糖尿病、用药史、运动及髋部骨折等混杂因素进行了适当调整。
应用纳入和排除标准后,纳入了CHARLS的5224名受试者(男性:52.2%,女性:47.8%)以及创伤骨科病房的174名患者(男性:36.2%,女性:63.8%)。分析显示,60岁及以上患者的衰弱评分每增加1分,跌倒风险增加之间存在强关联(CHARLS,比值比:1.53,95%置信区间:1.41 - 1.66;单中心,比值比:1.57,95%置信区间:0.92 - 2.71)。与对照组相比,这种关联在衰弱前期(CHARLS,比值比:1.95,95%置信区间:1.65 - 2.32;单中心,比值比:1.67,95%置信区间:0.46 - 6.08)和衰弱组(CHARLS,比值比:3.43,95%置信区间:2.51 - 4.68;单中心,比值比:4.01,95%置信区间:0.61 - 26.41)中更为明显。亚组研究显示,髋部骨折患者中衰弱与跌倒之间存在性别相关的交互作用,而社区居住的老年人中则不存在。此外,RCS回归显示两组中衰弱与跌倒之间均呈线性相关。
本研究发现CHARLS及单中心髋部骨折患者的衰弱状况与跌倒之间存在正相关。仅在髋部骨折患者中观察到这种关系存在性别差异。这些发现凸显了衰弱对社区工作者和临床医生的重要性。