Jalloul Mohammad, Venkatakrishna Shyam Sunder B, Alves Cesar Augusto P, Curic Jelena, Andronikou Savvas
Department of Radiology, Children's Hospital of Philadelphia, Roberts Center for Pediatric Research, Philadelphia, PA.
Graduate MBA Program, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Cambridge, United Kingdom.
J Comput Assist Tomogr. 2025;49(2):327-331. doi: 10.1097/RCT.0000000000001668. Epub 2024 Nov 18.
This study examined the occurrence and MRI characteristics of perinatal arterial ischemic stroke (PAIS) in children with cerebral palsy (CP) and suspected term hypoxic-ischemic injury (HII).
A retrospective review of brain MRI scans was conducted on children with CP and suspected term HII in South Africa.
Out of 1620 children with CP included in the study, 15 (0.9%) had PAIS. The most common site of infarct was the left middle cerebral artery. The majority of infarcts were unilateral, and 67% of cases exhibited cystic changes. Among children with PAIS, 47% exhibited concurrent HII, with the predominant patterns being basal-ganglia-thalamus (BGT) and watershed (WS). In cases of isolated PAIS (53%), network injuries were prevalent in 88% of children, most commonly involving the posterior limbs of the internal capsule, cerebral peduncles, thalami, and corpus callosum.
The study highlights that PAIS is a relatively rare condition in children with CP, predominantly occurring in the left middle cerebral artery.
本研究调查了脑瘫（CP）患儿及疑似足月缺氧缺血性损伤（HII）患儿围产期动脉缺血性卒中（PAIS）的发生率及MRI特征。
对南非患有CP及疑似足月HII的儿童进行脑部MRI扫描回顾性分析。
纳入研究的1620例CP患儿中，15例（0.9%）发生PAIS。梗死最常见部位是左侧大脑中动脉。大多数梗死为单侧，67%的病例出现囊性改变。PAIS患儿中，47%同时存在HII，主要类型为基底节-丘脑（BGT）和分水岭（WS）型。在孤立性PAIS病例（53%）中，88%的患儿存在网络损伤，最常累及内囊后肢、脑桥、丘脑和胼胝体。
该研究强调PAIS在CP患儿中相对少见，主要发生于左侧大脑中动脉。
