Li Jun, Wang Linbin, Pan Yixin, Huang Peng, Xu Lu, Zhang Yuyao, De Ridder Dirk, Voon Valerie, Li Dianyou
Center for Functional Neurosurgery, Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; School of Information Science and Technology, ShanghaiTech University, Shanghai, China.
Center for Functional Neurosurgery, Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
J Affect Disord. 2025 Mar 15;373:314-324. doi: 10.1016/j.jad.2025.01.005. Epub 2025 Jan 4.
Parkinson's disease (PD) is primarily characterized by motor symptoms, but patients also experience a relatively high prevalence of non-motor symptoms, including emotional and cognitive impairments. While the subthalamic nucleus (STN) is a common target for deep brain stimulation to treat motor symptoms in PD, its role in emotion processing is still under investigation. This study examines the subthalamic neural oscillatory activities during facial emotion processing and its association with affective characteristics.
Twenty PD patients who underwent subthalamic deep brain stimulation surgery performed a facial-expression-recognition task while STN local field potential (LFP) and frontal electroencephalography (EEG) were recorded. The facial-emotion-induced time-frequency decomposition of the STN-LFP and the frontal EEG, as well as the LFP-EEG coherence, were analyzed. Furthermore, the correlation between STN activities and affective characteristics was examined.
Facial expressions elicited increased delta-theta-band and decreased alpha-beta-band activities in STN-LFP. Reduced alpha-beta-band LFP desynchronization was correlated with the severity of apathy. Increased theta-band and decreased alpha-beta-band EEG activities responded to facial emotion. Notably, lower coherence between STN-LFP and frontal EEG in delta-theta-band activity and alpha-band activity correlated with the degree of anhedonia.
These results indicate that subthalamic activities during facial emotion processing are associated with apathy and anhedonia, emphasizing the cognitive-limbic function of STN and its role as a physiological target for apathy neuromodulation in PD.
帕金森病（PD）主要以运动症状为特征，但患者也有相对较高比例的非运动症状，包括情绪和认知障碍。虽然丘脑底核（STN）是深部脑刺激治疗PD运动症状的常见靶点，但其在情绪加工中的作用仍在研究中。本研究考察了面部情绪加工过程中丘脑底核的神经振荡活动及其与情感特征的关联。
20例接受丘脑底核深部脑刺激手术的PD患者在记录丘脑底核局部场电位（LFP）和额叶脑电图（EEG）的同时进行面部表情识别任务。分析了面部情绪诱发的丘脑底核LFP和额叶EEG的时频分解以及LFP-EEG相干性。此外，还考察了丘脑底核活动与情感特征之间的相关性。
面部表情使丘脑底核LFP中的δ-θ频段活动增加，α-β频段活动减少。α-β频段LFP去同步化降低与淡漠严重程度相关。θ频段活动增加和α-β频段EEG活动减少对面部情绪有反应。值得注意的是，δ-θ频段活动和α频段活动中丘脑底核LFP与额叶EEG之间较低的相干性与快感缺失程度相关。
这些结果表明，面部情绪加工过程中的丘脑底核活动与淡漠和快感缺失相关，强调了丘脑底核的认知-边缘系统功能及其作为PD淡漠神经调节生理靶点的作用。
