Chen Hong, Luo Hua, Zhou Ju, Yu Ming, Qing Ting, Wang Yanfen, Shao Minjie, Wei Wei, Yi Xingyang
Department of Neurology, People's Hospital of Deyang City, Deyang, China.
Deyang People's Hospital, Sichuan Clinical Research Center for Neurological Diseases, Deyang, China.
J Cent Nerv Syst Dis. 2025 Jan 3;17:11795735241312660. doi: 10.1177/11795735241312660. eCollection 2025.
The association of genetic single-nucleotide polymorphisms (SNPs) related to endothelial function, inflammation, and their outcomes remains poorly studied.
To evaluate the occurrence of ischemic stroke (IS) and other vascular events, and relationships between 19 SNPs in genes associated with endothelial function and inflammation with outcomes in a population at high risk of stroke.
A prospective cohort study and multi-center community-based sectional survey.
As a part of the China National Stroke Screening Survey program, the investigation was carried out in southern China from May 2015 to January 2020. Participants from 8 randomly selected. In people who were determined to be at high risk of stroke, 19 SNPs were examined. Over an average follow-up period of 4.7 years, the results of these subjects were monitored using a longitudinal method. A new IS was the primary outcome assessed, and a combination of new vascular events was the secondary outcome.
In total, 2893 participants were classified as high-risk for stroke, and 2698 were monitored for 4.7 years, resulting in 192 participants (7.1%) experiencing various outcomes. Out of these, 118 individuals (4.4%) had a novel IS, 24 (0.9%) suffered a hemorrhagic stroke (HS), 53 (2.0%) developed myocardial infarction (MI), and 33 (1.2%) passed away. Significant variations have been found in the genotype distributions of rs752998, rs4845625, and rs3093662 among participants with adverse outcomes compared to those without. Generalized multifactor dimensionality reduction (GMDR) analysis identified a substantial SNP-SNP interaction involving rs932650, rs1927911, and rs4845625 ( = .004). The high-risk genotypes of these 3 SNPs were linked to an increased risk of IS (OR = 2.186, 95% CI: 1.247-5.426, < .001) and total vascular events (OR = 2.367, 95% CI: 1.433-5.798, < .001), according to multivariate logistic regression adjusted for covariates.
The incidence of IS and other vascular events was significantly greater among participants who were categorized as being at high risk for stroke. The interacting high-risk genotypes of rs932650, rs1927911 and rs4845625 were independently associated with an increased risk of new IS and other vascular events.
与内皮功能、炎症及其后果相关的基因单核苷酸多态性（SNP）之间的关联研究仍较少。
评估缺血性卒中（IS）和其他血管事件的发生率，以及与内皮功能和炎症相关基因中的19个SNP与卒中高危人群预后之间的关系。
一项前瞻性队列研究和基于社区的多中心横断面调查。
作为中国国家卒中筛查调查项目的一部分，于2015年5月至2020年1月在中国南方进行调查。从8个随机选择的地区招募参与者。在确定为卒中高危的人群中，检测了19个SNP。在平均4.7年的随访期内，采用纵向方法监测这些受试者的结果。新发IS是主要评估结局，新发血管事件的组合是次要结局。
共有2893名参与者被归类为卒中高危人群，2698人接受了4.7年的监测，导致192名参与者（7.1%）出现各种结局。其中，118人（4.4%）发生新发IS，24人（0.9%）发生出血性卒中（HS），53人（2.0%）发生心肌梗死（MI），33人（1.2%）死亡。与未出现不良结局的参与者相比，rs752998、rs4845625和rs3093662的基因型分布存在显著差异。广义多因素降维（GMDR）分析确定了一个涉及rs932650、rs1927911和rs4845625的显著SNP-SNP相互作用（P = 0.004）。根据对协变量进行调整的多变量逻辑回归分析，这3个SNP的高危基因型与IS风险增加（OR = 2.186，95%CI：1.247 - 5.426，P < 0.001）和总血管事件风险增加（OR = 2.367，95%CI：1.433 - 5.798，P < 0.001）相关。
在被归类为卒中高危的参与者中，IS和其他血管事件的发生率显著更高。rs932650、rs1927911和rs4845625相互作用的高危基因型与新发IS和其他血管事件风险增加独立相关。
