体内谱系追踪衰老表明，并非所有衰老细胞都是一样的。
Lineage tracing senescence in vivo shows not all senescent cells are created equal.
作者信息
Ruscetti Marcus
机构信息
Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
出版信息
Dev Cell. 2025 Jan 6;60(1):3-4. doi: 10.1016/j.devcel.2024.12.008.
PMID:39765222
Abstract
Understanding the impact of senescence on disease is limited by the lack of tools to lineage label senescent cells. In a recent Cell issue, Zhao et al. create mouse models to genetically manipulate and trace p16 cells, identifying contrasting roles for senescent macrophages and endothelial cells (ECs) in liver fibrosis.
摘要
由于缺乏对衰老细胞进行谱系标记的工具，我们对衰老在疾病中的影响的理解受到了限制。在最近一期的《细胞》杂志上，赵等人创建了小鼠模型，以对p16细胞进行基因操作和追踪，从而确定衰老的巨噬细胞和内皮细胞（ECs）在肝纤维化中的不同作用。
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