Kiseleva Olga I, Arzumanian Viktoriia A, Ikhalaynen Yuriy A, Kurbatov Ilya Y, Kryukova Polina A, Poverennaya Ekaterina V
Institute of Biomedical Chemistry, Pogodinskaya Street, 10/8, 119121 Moscow, Russia.
Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.
Int J Mol Sci. 2024 Dec 21;25(24):13671. doi: 10.3390/ijms252413671.
Despite their astonishing biological diversity, surprisingly few shared traits connect all or nearly all living organisms. Aging, i.e., the progressive and irreversible decline in the function of multiple cells and tissues, is one of these fundamental features of all organisms, ranging from single-cell creatures to complex animals, alongside variability, adaptation, growth, healing, reproducibility, mobility, and, finally, death. Age is a key determinant for many pathologies, shaping the risks of incidence, severity, and treatment outcomes for cancer, neurodegeneration, heart failure, sarcopenia, atherosclerosis, osteoporosis, and many other diseases. In this review, we aim to systematically investigate the age-related features of the development of several diseases through the lens of multiomics: from genome instability and somatic mutations to pathway alterations and dysregulated metabolism.
尽管生物具有惊人的多样性，但令人惊讶的是，连接所有或几乎所有生物的共同特征却很少。衰老，即多个细胞和组织功能的渐进性和不可逆性衰退，是所有生物（从单细胞生物到复杂动物）的基本特征之一，其他基本特征还包括变异性、适应性、生长、愈合、可复制性、移动性，以及最终的死亡。年龄是许多疾病的关键决定因素，影响着癌症、神经退行性疾病、心力衰竭、肌肉减少症、动脉粥样硬化、骨质疏松症和许多其他疾病的发病风险、严重程度及治疗结果。在本综述中，我们旨在通过多组学视角系统地研究几种疾病发展过程中与年龄相关的特征：从基因组不稳定性和体细胞突变到信号通路改变和代谢失调。
