全蝎的显著治疗作用：离子通道的现代科学探索

Zheng Yueyuan, Wen Qiuyi, Huang Yushi, Guo Dean

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.

Pharmaceuticals (Basel). 2024 Dec 22;17(12):1735. doi: 10.3390/ph17121735.

Chinese scorpion (CS), a traditional animal-based medicine used for over a millennium, has been documented since AD 935-960. It is derived from the scorpion Karsch and is used to treat various ailments such as stroke, epilepsy, rheumatism, and more. Modern research has identified the pharmacological mechanisms behind its traditional uses, with active components like venom and proteins showing analgesic, antitumor, antiepileptic, and antithrombotic effects. Studies reveal that CS affects ion channels, crucial for cellular functions, through interactions with sodium, potassium, and calcium channels, potentially explaining its therapeutic effects. Future research aims to elucidate the precise mechanisms, target specific ion channel subtypes, and validate clinical efficacy and safety, paving the way for novel therapies based on these natural compounds.

中药全蝎是一种使用了一千多年的传统动物药，自公元935年至960年就有记载。它来源于东亚钳蝎，用于治疗各种疾病，如中风、癫痫、风湿等。现代研究已经确定了其传统用途背后的药理机制，毒液和蛋白质等活性成分具有镇痛、抗肿瘤、抗癫痫和抗血栓作用。研究表明，全蝎通过与钠、钾和钙通道相互作用来影响对细胞功能至关重要的离子通道，这可能解释了它的治疗效果。未来的研究旨在阐明其精确机制，针对特定的离子通道亚型，并验证临床疗效和安全性，为基于这些天然化合物的新型疗法铺平道路。