Alqumber Mohammed Abdullah
Laboratory Medicine Department, Faculty of Applied Medical Sciences, Albaha University, Al Bahah 65779, Albaha, Saudi Arabia.
Microorganisms. 2024 Nov 25;12(12):2421. doi: 10.3390/microorganisms12122421.
This study investigates parasitic and bacterial pathogens present in Hamadryas baboons () and humans in southwestern Saudi Arabia. Fecal samples were collected from Hamadryas baboons ( = 999) from three city peripheries and humans from city centers ( = 1998) and peripheries ( = 1998) of southwestern and eastern Saudi cities. Parasitic examinations and bacterial cultures were conducted on these samples. Key findings include the identification of various parasitic and bacterial pathogens, with notable prevalences of (71.37% in baboons, 71.51% in humans), (42.24% in baboons, 17.85% in humans), spp. (40.14% in baboons, 12.6% in humans), hookworms (37.44% in baboons, 18.57% in humans), spp. (37.34% in baboons, 17.39% in humans), (36.34% in baboons, 11.18% in humans), and spp. (29.73% in baboons, 1.86% in humans). Additionally, the prevalences of these microorganisms in human populations coexisting with baboons in southwestern city peripheries were 75.47%, 25.22%, 23.62%, 26.33%, 22.22%, 15.11%, and 3.8%, respectively. To further characterize bacterial isolates, RNA gene sequencing was used, suggesting potential zoonotic and anthroponotic cycles. The results highlight significant pathogen prevalence among both baboons and human populations in proximity to baboon habitats, indicating a potential public health risk. However, shared environmental sources, such as contaminated water, were not thoroughly assessed and could play a role in pathogen transmission. The study's focus on 18 different parasitic and bacterial pathogens allowed for the targeting of prevalent and indicative markers of zoonotic and anthroponotic transmission. In conclusion, these baseline data are crucial for the design of advanced studies to further investigate the zoonotic and anthroponotic transmission dynamics and the environmental factors influencing pathogen prevalence.
本研究调查了沙特阿拉伯西南部阿拉伯狒狒和人类体内存在的寄生虫和细菌病原体。从三个城市周边地区的阿拉伯狒狒（n = 999）以及沙特西南部和东部城市市中心（n = 1998）和周边地区（n = 1998）的人类中采集粪便样本。对这些样本进行了寄生虫检查和细菌培养。主要发现包括鉴定出各种寄生虫和细菌病原体，其中显著的流行率有：溶组织内阿米巴（狒狒中为71.37%，人类中为71.51%）、蓝氏贾第鞭毛虫（狒狒中为42.24%，人类中为17.85%）、隐孢子虫属（狒狒中为40.14%，人类中为12.6%）、钩虫（狒狒中为37.44%，人类中为18.57%）、微小隐孢子虫属（狒狒中为37.34%，人类中为17.39%）、结肠小袋纤毛虫（狒狒中为36.34%，人类中为11.18%）以及芽囊原虫属（狒狒中为29.73%，人类中为1.86%）。此外，在西南部城市周边地区与狒狒共存的人群中，这些微生物的流行率分别为75.47%、25.22%、23.62%、26.33%、22.22%、15.11%和3.8%。为了进一步表征细菌分离株，使用了RNA基因测序，这表明存在潜在的人畜共患病和人传人循环。结果突出了在狒狒栖息地附近的狒狒和人群中病原体的显著流行率，表明存在潜在的公共卫生风险。然而，诸如受污染水等共享环境来源未得到充分评估，可能在病原体传播中起作用。该研究对18种不同的寄生虫和细菌病原体的关注使得能够针对人畜共患病和人传人传播的流行和指示性标志物。总之，这些基线数据对于设计进一步研究人畜共患病和人传人传播动态以及影响病原体流行率的环境因素的高级研究至关重要。
