Budiman Arif, Hafidz Nur Parida Mahdhani, Azzahra Raden Siti Salma, Amaliah Salma, Sitinjak Feggy Yustika, Rusdin Agus, Subra Laila, Aulifa Diah Lia
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Bandung 45363, Indonesia.
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Bandung 45363, Indonesia.
Polymers (Basel). 2024 Dec 14;16(24):3489. doi: 10.3390/polym16243489.
Plant extracts demonstrate significant potential as a rich source of active pharmaceutical ingredients, exhibiting diverse biological activities and minimal toxicity. However, the low aqueous solubility of extracts and their gastrointestinal permeability, as well as their poor oral bioavailability, limit clinical advancements due to drug delivery problems. An amorphous solid dispersion (ASD) delivers drugs by changing an active pharmaceutical ingredient (API) into an amorphous state to increase the solubility and availability of the API to the body. This research aimed to analyze and summarize the successful advancements of ASD systems derived from plant extracts, emphasizing characterization and the effects on dissolution and pharmacological activity. The results show that ASD systems improve phytoconstituent dissolution, bioavailability, and stability, in addition to reducing dose and toxicity. This research demonstrates the significance of ASD in therapeutic formulations to augment the pharmacological activities and efficacy of medicinal plant extracts. The prospects indicate promising potential for therapeutic applications utilizing ASD systems, alongside medicinal plant extracts for clinical therapy.
植物提取物作为丰富的活性药物成分来源显示出巨大潜力，具有多种生物活性且毒性极小。然而，提取物的低水溶性及其胃肠道渗透性，以及较差的口服生物利用度，由于药物递送问题限制了临床进展。无定形固体分散体（ASD）通过将活性药物成分（API）转变为无定形状态来递送药物，以增加API在体内的溶解度和可用性。本研究旨在分析和总结源自植物提取物的ASD系统的成功进展，重点关注表征以及对溶解和药理活性的影响。结果表明，ASD系统除了降低剂量和毒性外，还能改善植物成分的溶解、生物利用度和稳定性。本研究证明了ASD在治疗制剂中增强药用植物提取物的药理活性和功效的重要性。前景表明，利用ASD系统以及药用植物提取物进行临床治疗具有广阔的治疗应用潜力。
