Elmelegy Nader Gomaa, Nader Dalia
Department of Plastic Surgery, Faculty of Medicine, Tanta University, Tanta, Egypt.
Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt.
J Orthop Surg Res. 2025 Jan 7;20(1):16. doi: 10.1186/s13018-024-05387-3.
The palmar aponeurosis is extremely adherent to the skin above it. Many of the pre-tendinous coarse fibers enter the dermis at an angle, not just in the palmar creases but also throughout the palm. It's difficult to distinguish whether Dupuytren's illness starts in the skin's dermis or the palmar aponeurosis since the skin adheres so closely to the palmar fascia. In this work, we have investigated the clinical and histological origins of Dupuytren's disease, as well as its impact on the disease's management.
A clinical prospective study was conducted on 47 patients, 42 males and 5 females, who presented with Dupuytren's contracture in the hands (29 patients were bilateral and 18 one-sided), in the period between April 2012 and September 2020.
Histologically, all our specimens showed chronic inflammatory skin lesions showing hyperkeratotic epidermal covering and dermal infiltration with aggregates of chronic inflammatory cells, mainly lymphocytes and plasma cells, proliferated vascular spaces, and fibrous stroma. Clinical satisfaction was excellent in 67(88.2%) hands, good in six (7.8%)hands, fair in three (4%) hands, and no poor results.
Dupuytren's disease is a chronic inflammatory skin illness that can penetrate fascia, as we've proved histologically and surgically. For a considerable reduction in recurrence, the adhering skin and accompanying cord must be removed.
IV - therapeutic study.
掌腱膜与其上方的皮肤紧密相连。许多腱前粗纤维以一定角度进入真皮,不仅在掌纹处,而且在整个手掌都如此。由于皮肤与掌腱膜紧密相连,很难区分杜普伊特伦病是始于皮肤真皮还是掌腱膜。在这项研究中,我们调查了杜普伊特伦病的临床和组织学起源,以及其对疾病治疗的影响。
2012年4月至2020年9月期间,对47例手部患有杜普伊特伦挛缩症的患者进行了临床前瞻性研究,其中男性42例,女性5例(29例为双侧,18例为单侧)。
组织学上,我们所有的标本均显示慢性炎症性皮肤病变,表现为角化过度的表皮覆盖、真皮内有慢性炎症细胞(主要是淋巴细胞和浆细胞)聚集、血管间隙增生以及纤维性基质。67只手(88.2%)临床满意度为优,6只手(7.8%)为良,3只手(4%)为中,无差的结果。
正如我们在组织学和手术中所证明的,杜普伊特伦病是一种可穿透筋膜的慢性炎症性皮肤病。为了显著降低复发率,必须切除粘连的皮肤和伴随的条索。
IV - 治疗性研究。