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Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand.

作者信息

Nilyanimit Pornjarim, Wanlapakorn Nasamon, Vichaiwattana Preeyaporn, Wongsrisang Lakkhana, Klinfueng Sirapa, Suntronwong Nungruthai, Bhunyakitikorn Wichan, Angsuwatcharakon Piyada, Sonthichai Chaninan, Thawinwisan Narong, Puedkuntod Pichet, Phattharasrivongchai Sunsanee, Loprakhon Parichaya, Tinnaitorn Watcharanan, Luankaew Thawatchai, Vinothai Sasithorn, Chaijaroen Somjet, Meechin Pornsawan, Pongpichit Chalermpol, Poovorawan Yong

机构信息

Centers of Excellence in Clinical Virology, Chulalongkorn University, Bangkok, Thailand.

Division of Communicable Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.

出版信息

Sci Rep. 2025 Jan 7;15(1):1167. doi: 10.1038/s41598-024-84854-7.

DOI:10.1038/s41598-024-84854-7
PMID:39774714
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11707173/
Abstract

This study aimed to evaluate the impact of Thailand's hepatitis B virus (HBV) National Program Immunization (NPI), 32 years post-implementation, on infection rates and immunity in various age groups. A cross-sectional study involved 6,068 participants aged 6 months to 80 years from four regions in Thailand. Blood samples were tested for HBsAg, anti-HBs, and anti-HBc using a chemiluminescent immunoassay. Data were compared across age groups and with previous surveys from 2004 to 2014. Individuals born after the implementation of the NPI had significantly lower HBV infection rates (p < 0.0001). No HBsAg was detected in individuals under 20 years old. The prevalence of HBV carriers increased with age, from 0.3% in the 21-30 group to 4.3% in those over 60, with an overall prevalence of 1.7%. Percentages of seroprotected individuals (anti-HBs ≥ 10 mIU/mL) were high in young children but dropped to 19.4% in ages 11-20 and 12.5% in ages 21-30. Anti-HBc was found at very low rates in children but increased significantly after age 30. Thailand's HBV NPI significantly reduced HBV infection rates, especially in younger populations. This study highlighted the program's success and guided future elimination efforts to achieve hepatitis elimination goal by 2030.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/11707173/f7d8b3c230be/41598_2024_84854_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/11707173/49b186adba29/41598_2024_84854_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/11707173/2bf4269bb879/41598_2024_84854_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/11707173/3e6f86afd036/41598_2024_84854_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/11707173/f7d8b3c230be/41598_2024_84854_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/11707173/49b186adba29/41598_2024_84854_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/11707173/2bf4269bb879/41598_2024_84854_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/11707173/3e6f86afd036/41598_2024_84854_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/11707173/f7d8b3c230be/41598_2024_84854_Fig4_HTML.jpg

相似文献

[1]
Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand.

Sci Rep. 2025-1-7

[2]
Seroprevalence of antibodies to hepatitis A, B and C viruses across all age groups in Chonburi Province, Thailand, 2022-2023.

Hum Vaccin Immunother. 2025-12

[3]
Low prevalence of hepatitis B vaccine escape mutants among individuals born after the initiation of a nationwide vaccination program in Iran.

Arch Virol. 2016-12

[4]
Seroprevalence of hepatitis B among the general population in Shandong Province, Eastern China, an update 30 years after the implementation of the neonatal vaccination program.

BMC Infect Dis. 2024-12-18

[5]
The Success of a Universal Hepatitis B Immunization Program as Part of Thailand's EPI after 22 Years' Implementation.

PLoS One. 2016-3-3

[6]
The first five years of universal hepatitis B vaccination in South Africa: evidence for elimination of HBsAg carriage in under 5-year-olds.

Vaccine. 2001-7-16

[7]
Hepatitis B surface antibodies seroprevalence among people born before and after implementation of universal HBV vaccination.

Vaccine. 2020-3-10

[8]
Continuing Decrease in Hepatitis B Virus Infection 30 Years After Initiation of Infant Vaccination Program in Taiwan.

Clin Gastroenterol Hepatol. 2016-5-4

[9]
Decrease in the prevalence of hepatitis B and D virus infections in an endemic area in Peru 23 years after the introduction of the first pilot vaccination program against hepatitis B.

PLoS One. 2020-8-6

[10]
Survey of hepatitis B virus infection status after 35 years of universal vaccination implementation in Taiwan.

Liver Int. 2024-8

引用本文的文献

[1]
Age associated SARS-CoV-2 immune responses provide insights into population immunity over four years since the COVID-19 pandemic.

Sci Rep. 2025-7-2

[2]
Epstein-Barr Virus Seroprevalence in Thailand: A Temporal and Global Perspective with Health Care and Economic Correlations.

Am J Trop Med Hyg. 2025-4-29

本文引用的文献

[1]
Survey of hepatitis B virus infection status after 35 years of universal vaccination implementation in Taiwan.

Liver Int. 2024-8

[2]
Immunogenicity of the pentavalent DTwP-HB-Hib vaccine (Shan-5) used in the Thai Expanded Program on Immunization compared to the hexavalent DTaP-HB-Hib-IPV and DTwP-HB-Hib (Quinvaxem) vaccines administered to infants at 2, 4, 6 months of age.

Vaccine. 2023-6-13

[3]
Towards the elimination of viral hepatitis in Thailand by the year 2030.

J Virus Erad. 2020-6-27

[4]
Implementation of hepatitis B vaccine in high-risk young adults with waning immunity.

PLoS One. 2018-8-20

[5]
Tenofovir versus Placebo to Prevent Perinatal Transmission of Hepatitis B.

N Engl J Med. 2018-3-8

[6]
Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer.

Gastroenterology. 2016-6-4

[7]
The Success of a Universal Hepatitis B Immunization Program as Part of Thailand's EPI after 22 Years' Implementation.

PLoS One. 2016-3-3

[8]
Long-term Protection After Hepatitis B Vaccine.

J Infect Dis. 2016-7-1

[9]
Changing incidence patterns of hepatocellular carcinoma among age groups in Taiwan.

J Hepatol. 2015-8-6

[10]
Hepatitis B and hepatitis C virus in Thai blood donors.

Southeast Asian J Trop Med Public Health. 2011-5

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