伴有气管透明假菊形团的EWSR1::BEND2腺癌。
EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea.
作者信息
Sanchez-Ramirez Juan J, Hoffman Matthew R, Keech John C, Snow Anthony N, Bellizzi Andrew M, Rajan Anand
机构信息
Department of Otolaryngology, 200 Hawkins Drive University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.
Department of Cardiothoracic Surgery, 200 Hawkins Drive University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.
出版信息
Head Neck Pathol. 2025 Jan 7;19(1):7. doi: 10.1007/s12105-024-01746-y.
We describe the novel occurrence of a adenocarcinoma involving the trachea, with distinct solid and glandular components, in a 34-year-old patient. We illustrate its morphological and immunophenotypic features and describe the molecular finding of an EWSR1::BEND2 gene fusion detected by next-generation sequencing (NGS). We discuss the findings in comparison to BEND2-fusion associated neoplasms reported in the head and neck region in the literature to date.
我们描述了一名34岁患者出现的累及气管的腺癌，具有明显的实性和腺性成分。我们展示了其形态学和免疫表型特征，并描述了通过二代测序（NGS）检测到的EWSR1::BEND2基因融合的分子发现。我们将这些发现与迄今为止文献中报道的头颈部区域与BEND2融合相关的肿瘤进行了比较讨论。
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