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肿瘤专家委员会在为异柠檬酸脱氢酶突变型神经胶质瘤患者开具异柠檬酸脱氢酶抑制剂时的作用。

Role of the tumor board when prescribing mutant isocitrate dehydrogenase inhibitors to patients with isocitrate dehydrogenase-mutant glioma.

作者信息

Roth Patrick, Capper David, Calabrese Evan, Halasz Lia M, Jakola Asgeir S

机构信息

University of Zurich, Zurich, Switzerland.

Department of Neurology and Brain Tumor Center, University Hospital Zurich, Zurich, Switzerland.

出版信息

Neurooncol Pract. 2024 Dec 4;12(Suppl 1):i29-i37. doi: 10.1093/nop/npae100. eCollection 2025 Feb.


DOI:10.1093/nop/npae100
PMID:39776528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11703365/
Abstract

Isocitrate dehydrogenase (IDH)-mutant gliomas, comprising both astrocytomas and oligodendrogliomas, represent a distinct group of tumors that pose an interdisciplinary challenge. Addressing the needs of affected patients requires close collaboration among various disciplines, including neuropathology, neuroradiology, neurosurgery, radiation oncology, neurology, medical oncology, and other relevant specialties when necessary. Interdisciplinary tumor boards are central in determining the ideal diagnostic and therapeutic strategies for these patients. The key tasks of a tumor board include the evaluation of imaging findings, selecting the appropriate surgical approach, discussing additional treatment options, and identification/determination of tumor recurrence and progression. In addition to established treatments such as radiotherapy and alkylating chemotherapy, patients with an isocitrate dehydrogenase (IDH)-mutant glioma for whom additional treatment is indicated may now also have the option of receiving treatment with an mutant isocitrate dehydrogenase inhibitor such as vorasidenib or ivosidenib. In this regard, the collaborative nature of tumor boards becomes even more crucial for evaluating comprehensively the needs of these patients. Through interdisciplinary discussions, tumor boards aim to develop personalized treatment strategies that maximize therapeutic efficacy while minimizing potential side effects and preserving patients' quality of life.

摘要

异柠檬酸脱氢酶(IDH)突变型胶质瘤,包括星形细胞瘤和少突胶质细胞瘤,是一类独特的肿瘤,带来了跨学科挑战。满足受影响患者的需求需要多学科密切合作,包括神经病理学、神经放射学、神经外科、放射肿瘤学、神经病学、医学肿瘤学以及必要时的其他相关专业。跨学科肿瘤委员会对于确定这些患者的理想诊断和治疗策略至关重要。肿瘤委员会的关键任务包括评估影像学检查结果、选择合适的手术入路、讨论其他治疗方案以及识别/确定肿瘤复发和进展。除了放疗和烷化剂化疗等既定治疗方法外,对于有额外治疗指征的异柠檬酸脱氢酶(IDH)突变型胶质瘤患者,现在也可以选择接受突变型异柠檬酸脱氢酶抑制剂(如沃拉西尼或艾伏尼布)治疗。在这方面,肿瘤委员会的协作性质对于全面评估这些患者的需求变得更加关键。通过跨学科讨论,肿瘤委员会旨在制定个性化治疗策略,在最大限度提高治疗效果的同时,尽量减少潜在副作用并维持患者的生活质量。

相似文献

[1]
Role of the tumor board when prescribing mutant isocitrate dehydrogenase inhibitors to patients with isocitrate dehydrogenase-mutant glioma.

Neurooncol Pract. 2024-12-4

[2]
The role of vorasidenib in the treatment of isocitrate dehydrogenase-mutant glioma.

Neuro Oncol. 2024-12-25

[3]
Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation.

Cochrane Database Syst Rev. 2018-1-22

[4]
Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma.

Acta Neuropathol. 2024-7-16

[5]
Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.

Cochrane Database Syst Rev. 2022-3-2

[6]
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Arch Ital Urol Androl. 2025-6-30

[7]
The IDH paradox: Meta-analysis of alkylating chemotherapy in IDH-wild type and -mutant lower grade gliomas.

Neuro Oncol. 2024-10-3

[8]
Systematic Review of Molecular Targeted Therapies for Adult-Type Diffuse Glioma: An Analysis of Clinical and Laboratory Studies.

Int J Mol Sci. 2023-6-21

[9]
The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation.

Health Technol Assess. 2007-11

[10]
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma.

N Engl J Med. 2023-8-17

本文引用的文献

[1]
Use, access, and initial outcomes of off-label ivosidenib in patients with IDH1 mutant glioma.

Neurooncol Pract. 2023-10-14

[2]
The role of molecular tumor boards in neuro-oncology: a nationwide survey.

BMC Cancer. 2024-1-19

[3]
Improved prognostic stratification of patients with isocitrate dehydrogenase-mutant astrocytoma.

Acta Neuropathol. 2024-1-6

[4]
PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): a report of the RANO group.

Lancet Oncol. 2024-1

[5]
Refinement of prognostication for IDH-mutant astrocytomas using DNA methylation-based classification.

Brain Pathol. 2024-9

[6]
The potential of amino acid PET imaging for prediction and monitoring of vorasidenib response in IDH-mutant gliomas.

Neuro Oncol. 2024-3-4

[7]
Ultra-fast deep-learned CNS tumour classification during surgery.

Nature. 2023-10

[8]
RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults.

J Clin Oncol. 2023-11-20

[9]
Diagnostic accuracy of glioma pseudoprogression identification with positron emission tomography imaging: a systematic review and meta-analysis.

Quant Imaging Med Surg. 2023-8-1

[10]
Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium.

Neuroradiology. 2023-9

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