Carvajal-Campos Amaranta, Trebossen Lucile, Jeusette Isabelle, Mayot Gilles, Torre Celina, Fragua Victor, Fernandez Anna, Martino Patrick Di
Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellule (ERRMECe) Laboratory, Site de St-Martin, CY Cergy Paris University, 95302 Cergy-Pontoise, France.
Research & Development, Affinity Petcare, 99134 Barcelona, Spain.
J Vet Res. 2024 Oct 9;68(4):583-587. doi: 10.2478/jvetres-2024-0055. eCollection 2024 Dec.
is the most common uropathogen in humans, dogs and cats. Dietary consumption of cranberry () is known to be associated with a reduction in uropathogenic (UPEC) adhesion to human and canine urinary epithelial cell lines, but this has not been shown in cats.
Six neutered domestic cats, one male and five females, were randomly fed three diets successively, one containing 0.1% cranberry powder, one containing 0.3% cranberry powder, and one being the control without cranberry. Naturally emitted urine was collected on the last two days of each period of two weeks and used for bacterial growth. Adherence to Crandell-Rees feline kidney (CRFK) uroepithelial cells of the feline UPEC C571 strain (positive for the C gene marker for P-fimbriae and the A marker for type 1 pili and negative for the gene of the alpha haemolysin cytotoxin A, and additionally non-haemolytic on blood agar) was quantified after growth in urine samples.
Significant reductions in bacterial adherence to CRFK cells were observed for 60% of cats receiving 0.1% cranberry powder supplementation and for all cats receiving 0.3% cranberry powder supplementation, compared to the same animals consuming the control diet.
Dietary supplementation with cranberry may provide some degree of protection to cats against adhesion of UPEC to feline uroepithelial cells.
大肠杆菌是人类、犬类和猫类中最常见的尿路致病菌。已知食用蔓越莓与尿路致病性大肠杆菌（UPEC）对人和犬类尿路上皮细胞系的黏附减少有关，但在猫身上尚未得到证实。
六只绝育的家猫，一只雄性和五只雌性，先后随机喂食三种日粮，一种含有0.1%蔓越莓粉，一种含有0.3%蔓越莓粉，一种为不含蔓越莓的对照日粮。在每两周的每个阶段的最后两天收集自然排出的尿液，用于细菌培养。在尿液样本中培养后，对猫UPEC C571菌株（P菌毛C基因标记和1型菌毛A标记呈阳性，α溶血素细胞毒素A基因呈阴性，且在血琼脂上不溶血）对Crandell-Rees猫肾（CRFK）尿路上皮细胞的黏附进行定量。
与食用对照日粮的同一动物相比，60%接受0.1%蔓越莓粉补充的猫和所有接受0.3%蔓越莓粉补充的猫对CRFK细胞的细菌黏附显著减少。
日粮中补充蔓越莓可能为猫提供一定程度的保护，防止UPEC黏附于猫尿路上皮细胞。
