• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

研究正中神经刺激后神经代谢物的变化。

Investigating Neurometabolite Changes in Response to Median Nerve Stimulation.

作者信息

Houlgreave Mairi S, Dyke Katherine, Berrington Adam, Jackson Stephen R

机构信息

School of Psychology, University of Nottingham University Park, Nottingham, UK.

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham University Park, Nottingham, UK.

出版信息

Brain Behav. 2025 Jan;15(1):e70250. doi: 10.1002/brb3.70250.

DOI:10.1002/brb3.70250
PMID:39779218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11710890/
Abstract

BACKGROUND

Rhythmic median nerve stimulation (MNS) at 10 Hz has been shown to cause a substantial reduction in tic frequency in individuals with Tourette syndrome. The mechanism of action is currently unknown but is hypothesized to involve entrainment of oscillations within the sensorimotor cortex.

OBJECTIVE

We used functional magnetic resonance spectroscopy (fMRS) to explore the dynamic effects of MNS on neurometabolite concentrations.

METHODS

Here, we investigated the effects of rhythmic and arrhythmic 10 Hz MNS on glutamate (Glu) and GABA concentrations in the contralateral sensorimotor cortex in 15 healthy controls, using a blocked fMRS design. We used a Mescher-Garwood-semi-localized by adiabatic selective refocusing (MEGA-sLASER) sequence at 7 T.

RESULTS

Our results show no difference in the difference-from-baseline measures between the two stimulation conditions. Looking at the effect of MNS over both conditions there is a trend for an initial increase in Glu/tCr (total creatine) followed by a decrease over time, whereas GABA/tCr decreased during each stimulation block.

CONCLUSIONS

These results suggest that despite entrainment of oscillations during rhythmic MNS, there are no significant differences in the tonic neuromodulatory effects of rhythmic and arrhythmic stimulation. The reduction in Glu over the course of stimulation may reflect a decrease in the glutamatergic firing due to adaptation. This may make it less likely that an involuntary movement is generated during continuous stimulation.

摘要

背景

已证明以10赫兹频率有节奏地刺激正中神经（MNS）可使患有图雷特综合征的个体的抽搐频率大幅降低。目前尚不清楚其作用机制，但据推测可能涉及感觉运动皮层内振荡的同步化。

目的

我们使用功能磁共振波谱（fMRS）来探究MNS对神经代谢物浓度的动态影响。

方法

在此，我们采用阻断式fMRS设计，研究了有节奏和无节奏的10赫兹MNS对15名健康对照者对侧感觉运动皮层中谷氨酸（Glu）和γ-氨基丁酸（GABA）浓度的影响。我们在7T磁场下使用了绝热选择性重聚焦半定位的Mescher-Garwood序列（MEGA-sLASER）。

结果

我们的结果表明，两种刺激条件下与基线相比的测量差异并无不同。综合两种条件下观察MNS的影响，Glu/总肌酸（tCr）有先升高后随时间下降的趋势，而在每个刺激时段内GABA/tCr均下降。

结论

这些结果表明，尽管有节奏的MNS期间存在振荡同步化，但有节奏和无节奏刺激的强直性神经调节作用并无显著差异。刺激过程中Glu的减少可能反映了由于适应性导致的谷氨酸能神经元放电减少。这可能使得在持续刺激期间产生非自主运动的可能性降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/35d28f7ad49a/BRB3-15-e70250-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/9a7f3484a84d/BRB3-15-e70250-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/81c1d8b04ebe/BRB3-15-e70250-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/cda7186f94c3/BRB3-15-e70250-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/2f21662a8593/BRB3-15-e70250-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/35d28f7ad49a/BRB3-15-e70250-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/9a7f3484a84d/BRB3-15-e70250-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/81c1d8b04ebe/BRB3-15-e70250-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/cda7186f94c3/BRB3-15-e70250-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/2f21662a8593/BRB3-15-e70250-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3250/11710890/35d28f7ad49a/BRB3-15-e70250-g004.jpg

相似文献

1
Investigating Neurometabolite Changes in Response to Median Nerve Stimulation.研究正中神经刺激后神经代谢物的变化。
Brain Behav. 2025 Jan;15(1):e70250. doi: 10.1002/brb3.70250.
2
Activation induced changes in GABA: Functional MRS at 7T with MEGA-sLASER.激活诱导的 GABA 变化：使用 MEGA-sLASER 的 7T 功能磁共振波谱。
Neuroimage. 2017 Aug 1;156:207-213. doi: 10.1016/j.neuroimage.2017.05.044. Epub 2017 May 19.
3
Longitudinal assessment of H-MRS (GABA and Glx) and TMS measures of cortical inhibition and facilitation in the sensorimotor cortex.对感觉运动皮层中 H-MRS（GABA 和 Glx）和 TMS 皮质抑制和易化测量值进行纵向评估。
Exp Brain Res. 2019 Dec;237(12):3461-3474. doi: 10.1007/s00221-019-05691-z. Epub 2019 Nov 16.
4
The oscillatory effects of rhythmic median nerve stimulation.节律性正中神经刺激的振荡效应。
Neuroimage. 2022 May 1;251:118990. doi: 10.1016/j.neuroimage.2022.118990. Epub 2022 Feb 11.
5
Functional Changes in GABA and Glutamate during Motor Learning.运动学习过程中 GABA 和谷氨酸的功能变化。
eNeuro. 2023 Feb 24;10(2). doi: 10.1523/ENEURO.0356-20.2023. Print 2023 Feb.
6
In vivo Glx and Glu measurements from GABA-edited MRS at 3 T.在 3T 场强下 GABA 编辑的 MRS 的活体 Glx 和 Glu 测量。
NMR Biomed. 2021 May;34(5):e4245. doi: 10.1002/nbm.4245. Epub 2020 Jan 28.
7
MASE-sLASER, a short-TE, matched chemical shift displacement error sequence for single-voxel spectroscopy at ultrahigh field.MASE-sLASER，一种用于超高场下单体素光谱分析的短回波时间、匹配化学位移位移误差序列。
NMR Biomed. 2018 Jul;31(7):e3940. doi: 10.1002/nbm.3940. Epub 2018 Jun 1.
8
Beta Peak Frequencies at Rest Correlate with Endogenous GABA+/Cr Concentrations in Sensorimotor Cortex Areas.静息状态下的β波峰频率与感觉运动皮层区域内源性GABA+/Cr浓度相关。
PLoS One. 2016 Jun 3;11(6):e0156829. doi: 10.1371/journal.pone.0156829. eCollection 2016.
9
Entraining Movement-Related Brain Oscillations to Suppress Tics in Tourette Syndrome.诱发运动相关脑振荡以抑制妥瑞氏症抽动。
Curr Biol. 2020 Jun 22;30(12):2334-2342.e3. doi: 10.1016/j.cub.2020.04.044. Epub 2020 Jun 4.
10
Quantification of GABA, glutamate and glutamine in a single measurement at 3 T using GABA-edited MEGA-PRESS.使用GABA编辑的MEGA-PRESS在3T磁场下单次测量中对GABA、谷氨酸和谷氨酰胺进行定量分析。
NMR Biomed. 2018 Jan;31(1). doi: 10.1002/nbm.3847. Epub 2017 Nov 12.

本文引用的文献

1
Universal dynamic fitting of magnetic resonance spectroscopy.磁共振波谱的通用动态拟合。
Magn Reson Med. 2024 Jun;91(6):2229-2246. doi: 10.1002/mrm.30001. Epub 2024 Jan 24.
2
A double-blind, sham-controlled, trial of home-administered rhythmic 10-Hz median nerve stimulation for the reduction of tics, and suppression of the urge-to-tic, in individuals with Tourette syndrome and chronic tic disorder.一项针对个体患有妥瑞氏症和慢性抽动障碍，通过家庭自主实施的节律性 10Hz 正中神经刺激，以减少抽动和抑制抽动冲动的双盲、假刺激对照试验。
J Neuropsychol. 2023 Sep;17(3):540-563. doi: 10.1111/jnp.12313. Epub 2023 May 3.
3
Median Nerve Stimulation for Treatment of Tics: A 4-Week Open Trial with Ecological Momentary Assessment.
正中神经刺激治疗抽动症：一项为期4周的采用生态瞬时评估的开放性试验。
J Clin Med. 2023 Mar 28;12(7):2545. doi: 10.3390/jcm12072545.
4
Median Nerve Stimulation for Treatment of Tics: Randomized, Controlled, Crossover Trial.正中神经刺激治疗抽动症：随机对照交叉试验
J Clin Med. 2023 Mar 27;12(7):2514. doi: 10.3390/jcm12072514.
5
The future is 2D: spectral-temporal fitting of dynamic MRS data provides exponential gains in precision over conventional approaches.未来是二维的：动态 MRS 数据的光谱-时间拟合比传统方法提供了指数级的精度增益。
Magn Reson Med. 2023 Feb;89(2):499-507. doi: 10.1002/mrm.29456. Epub 2022 Sep 19.
6
The oscillatory effects of rhythmic median nerve stimulation.节律性正中神经刺激的振荡效应。
Neuroimage. 2022 May 1;251:118990. doi: 10.1016/j.neuroimage.2022.118990. Epub 2022 Feb 11.
7
Peripheral Somatosensory Entrainment Modulates the Cross-Frequency Coupling of Movement-Related Theta-Gamma Oscillations.外周躯体感觉传入调制运动相关θ-γ振荡的跨频耦合。
Brain Connect. 2022 Aug;12(6):524-537. doi: 10.1089/brain.2021.0003. Epub 2021 Sep 3.
8
Relationship between GABA levels and task-dependent cortical excitability in children with attention-deficit/hyperactivity disorder.注意缺陷多动障碍儿童 GABA 水平与任务相关皮质兴奋性的关系。
Clin Neurophysiol. 2021 May;132(5):1163-1172. doi: 10.1016/j.clinph.2021.01.023. Epub 2021 Mar 10.
9
Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations.体内磁共振波谱学（MRSinMRS）最低报告标准：专家共识建议。
NMR Biomed. 2021 May;34(5):e4484. doi: 10.1002/nbm.4484. Epub 2021 Feb 9.
10
Increased Glutamate concentrations during prolonged motor activation as measured using functional Magnetic Resonance Spectroscopy at 3T.在 3T 场强下采用功能磁共振波谱测量得出，在长时间运动激活期间谷氨酸浓度增加。
Neuroimage. 2020 Dec;223:117338. doi: 10.1016/j.neuroimage.2020.117338. Epub 2020 Sep 5.