Rosca Ioana, Popescu Daniela-Eugenia, Jura Ana Maria Cristina, Turenschi Alina, Filip Cristina, Dinulescu Alexandru, Constantin Andreea T
Neonatology, University of Medicine and Pharmacy Carol Davila, Bucharest, ROU.
Neonatology, Clinic Hospital of Obstetrics and Gynecology Prof. Dr. Panait Sirbu, Bucharest, ROU.
Cureus. 2024 Dec 9;16(12):e75388. doi: 10.7759/cureus.75388. eCollection 2024 Dec.
Congenital heart disease (CHD) is diagnosed with high prevalence. Pulse oximetry and clinical examination are screening tools to aid in obtaining a CHD diagnosis.
We conducted a retrospective longitudinal study over three years, screening 1188 newborns admitted to the neonatal intensive care unit (NICU) during the first 72 hours of life.
Two hundred one newborns were diagnosed with CHD. Almost all (n=198) had a positive screening test during the 72 hours, while three had a negative screening test but were later diagnosed using echocardiography. The prevalence rate of CHD was 16.67%. A confusion matrix was constructed with 198 true positives (TP), 3 false negatives (FN), no false positives (FP), and 987 true negatives (TN). The sensitivity of the screening test was 98.51%, while the specificity was 100%, with no false positives. In our study, a total of nine deaths occurred due to CHD or complications of CHD. Using the Kaplan-Meier method, the survival probability appeared to be slightly above 0.9 (95.5%), indicating that almost all patients survived past 72 hours after being diagnosed with CHD.
Pulse oximetry is an effective, low-cost, and easy-to-use method that is useful for assessing and diagnosing CHD.
先天性心脏病(CHD)的诊断患病率很高。脉搏血氧饱和度测定和临床检查是有助于获得CHD诊断的筛查工具。
我们进行了一项为期三年的回顾性纵向研究,对出生后72小时内入住新生儿重症监护病房(NICU)的1188名新生儿进行了筛查。
201名新生儿被诊断为CHD。几乎所有患儿(n = 198)在72小时内筛查结果呈阳性,而3名患儿筛查结果为阴性,但后来通过超声心动图被诊断出患有CHD。CHD的患病率为16.67%。构建了一个混淆矩阵,其中有198个真阳性(TP)、3个假阴性(FN)、无假阳性(FP)和987个真阴性(TN)。筛查试验的敏感性为98.51%,特异性为100%,无假阳性。在我们的研究中,共有9例因CHD或CHD并发症死亡。使用Kaplan-Meier方法,生存概率似乎略高于0.9(95.5%),这表明几乎所有被诊断为CHD的患者在72小时后都存活了下来。
脉搏血氧饱和度测定是一种有效、低成本且易于使用的方法,对评估和诊断CHD很有用。