McGrath J C, MacLennan S J, Stuart-Smith K
Br J Pharmacol. 1985 Jan;84(1):199-202. doi: 10.1111/j.1476-5381.1985.tb17370.x.
The 5-hydroxytryptamine (5-HT) receptor in human umbilical artery was found to be similar to that in rabbit aorta. The pD2 was 7.45, pA2 for methysergide 8.63 and pA2 for phentolamine 6.21. Noradrenaline gave only very weak contractions at non-physiological concentrations. Amidephrine and xylazine did not contract human umbilical artery. It is concluded that there is no significant population of functional alpha-adrenoceptors in this vessel. The implications of these findings are discussed in relation to the control of the umbilical circulation.
研究发现，人脐动脉中的5-羟色胺（5-HT）受体与兔主动脉中的相似。其pD2为7.45，麦角新碱的pA2为8.63，酚妥拉明的pA2为6.21。去甲肾上腺素在非生理浓度下仅产生非常微弱的收缩作用。苯福林和赛拉嗪不会使人脐动脉收缩。由此得出结论，该血管中不存在大量功能性α-肾上腺素能受体。结合脐循环的调控对这些发现的意义进行了讨论。
