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恢复视力:眼药水与角膜缘干细胞存活

Revitalizing Vision: Eye Drops and Corneal Limbal Stem Cells Survival.

作者信息

Wang Yahui, Yousefi Mojdeh, Fard Mohammad Reza Ghasemzadeh, Masihpour Nasrin, Ali Khiavi Payam, Yousefi Khadije, Hajizadeh Maryam, KarkonShayan Sepideh

机构信息

School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.

Department of Ophthalmology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

出版信息

Stem Cell Rev Rep. 2025 Apr;21(3):730-743. doi: 10.1007/s12015-025-10841-8. Epub 2025 Jan 9.

DOI:10.1007/s12015-025-10841-8
PMID:39786675
Abstract

In the quest to transform vision care, researchers have been investigating novel methods to boost the efficacy of eye drops and enhance the survival of corneal limbal stem cells. Aimed at rejuvenating vision, these innovations seek to tackle a range of ocular conditions and restore sight to those in need. This article examines the most recent advancements in eye drops and corneal limbal stem cells, highlighting their potential to revolutionize ophthalmology. Findings from various studies indicate that the drive to rejuvenate vision has resulted in significant progress within the field of ophthalmology, especially regarding eye drops and corneal limbal stem cells. By improving the effectiveness of eye drops and increasing the survival rates of CLSCs, researchers are creating pathways for more sustainable and effective treatment options. These advancements offer great hope for patients experiencing various ocular issues, suggesting a future where vision restoration is attainable. As research continues to refine these strategies, we can look forward to an era marked by better visual outcomes and an enhanced quality of life for many individuals around the world.

摘要

在致力于变革视力保健的过程中,研究人员一直在研究新方法,以提高眼药水的功效并提高角膜缘干细胞的存活率。旨在恢复视力,这些创新旨在解决一系列眼部疾病,并为有需要的人恢复视力。本文探讨了眼药水和角膜缘干细胞的最新进展,突出了它们彻底改变眼科学的潜力。各项研究的结果表明,恢复视力的努力已在眼科学领域取得了重大进展,特别是在眼药水和角膜缘干细胞方面。通过提高眼药水的有效性和提高角膜缘干细胞的存活率,研究人员正在为更可持续和有效的治疗选择开辟道路。这些进展为患有各种眼部问题的患者带来了巨大希望,预示着未来视力恢复是可以实现的。随着研究不断完善这些策略,我们可以期待一个以更好的视觉效果和全球许多人生活质量提高为特征的时代。

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本文引用的文献

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Polymers and Biomaterials for Posterior Lamella of the Eyelid and the Lacrimal System.用于眼睑后层和泪液系统的聚合物与生物材料。
Polymers (Basel). 2024 Jan 28;16(3):352. doi: 10.3390/polym16030352.
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Paired Box Gene 6 Regulates Heme Oxygenase-1 Expression and Mitigates Hydrogen Peroxide-Induced Oxidative Stress in Lens Epithelial Cells.配对盒基因 6 调节血红素加氧酶-1 的表达并减轻晶状体上皮细胞中过氧化氢诱导的氧化应激。
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Treatment of Non-Infectious Corneal Injury: Review of Diagnostic Agents, Therapeutic Medications, and Future Targets.
非感染性角膜损伤的治疗:诊断试剂、治疗药物及未来靶点的综述。
Drugs. 2022 Feb;82(2):145-167. doi: 10.1007/s40265-021-01660-5. Epub 2022 Jan 13.
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Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes.间充质干细胞(MSC)衍生外泌体的治疗特性及最新临床试验
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Osteosarcoma tissue-engineered model challenges oxidative stress therapy revealing promoted cancer stem cell properties.成骨肉瘤组织工程模型挑战氧化应激治疗,揭示了促进癌症干细胞特性。
Free Radic Biol Med. 2021 Feb 20;164:107-118. doi: 10.1016/j.freeradbiomed.2020.12.437. Epub 2021 Jan 2.
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Characterization of the secretory profile and exosomes of limbal stem cells in the canine species.犬类角膜缘干细胞的分泌特征及外泌体研究。
PLoS One. 2020 Dec 29;15(12):e0244327. doi: 10.1371/journal.pone.0244327. eCollection 2020.
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Dose-dependent benzalkonium chloride toxicity imparts ocular surface epithelial changes with features of dry eye disease.剂量依赖性苯扎氯铵毒性导致眼表上皮改变,并伴有干眼疾病的特征。
Ocul Surf. 2020 Jan;18(1):158-169. doi: 10.1016/j.jtos.2019.11.006. Epub 2019 Nov 15.
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Limbal Epithelial and Mesenchymal Stem Cell Therapy for Corneal Regeneration.角膜再生的角膜缘上皮和间充质干细胞治疗。
Curr Eye Res. 2020 Mar;45(3):265-277. doi: 10.1080/02713683.2019.1639765. Epub 2019 Jul 19.
9
Comparison of growth factor and interleukin content of adult peripheral blood and cord blood serum eye drops for cornea and ocular surface diseases.用于角膜和眼表疾病的成人外周血和脐带血血清滴眼液中生长因子和白细胞介素含量的比较。
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Novel drug delivery systems for ocular therapy: With special reference to liposomal ocular delivery.用于眼部治疗的新型药物递送系统:特别提及脂质体眼部递送
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