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高精氨酸浓度与心肌梗死后最初几天内的早期抑郁症状及身体功能下降相关。

Homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction.

作者信息

Baranyi Andreas, Meinitzer Andreas, von Lewinski Dirk, Wagner-Skacel Jolana, Garcia Sabrina Leal, Rothenhäusler Hans-Bernd, Amouzadeh-Ghadikolai Omid, Harpf Leonhard, Schweinzer Melanie, Enko Dietmar

机构信息

Department of Psychiatry, Psychosomatics and Psychotherapeutic Medicine, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036, Graz, Austria.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036, Graz, Austria.

出版信息

Sci Rep. 2025 Jan 9;15(1):1520. doi: 10.1038/s41598-024-84930-y.

DOI:10.1038/s41598-024-84930-y
PMID:39789030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11718095/
Abstract

Early depressive symptoms within the first days after acute myocardial infarction (AMI) are mainly manifested with performance parameters (lack of energy, concentration difficulties, reduction in physical functioning). Homoarginine (hArg), a non-proteinogenic amino acid, might increase the availability of nitric oxide (NO). NO controls vasodilatation, blood flow, mitochondrial respiration and improves performance. Therefore, low plasma hArg levels after an AMI might impact performance-related early depressive symptoms. This longitudinal study aims to determine the course of plasma hArg concentrations immediately, on the fourth day and 6 months after AMI and investigates the associations between hArg and early depressive symptoms. A decrease in hArg levels, as observed in AMI patients on the fourth day after AMI, was independent of gender, age, body-mass-index and AMI type. After six months, hArg concentrations no longer differed significantly from baseline values. Females had lower hArg concentrations shortly after and also four days after the AMI compared to males. Within the first days after AMI HAMD-17 and BDI-II total depression scores and performance-related early depressive symptoms such as lack of energy, concentration difficulties and reduction in physical functioning correlated with low hArg concentrations.

摘要

急性心肌梗死（AMI）后最初几天内的早期抑郁症状主要表现为行为参数（精力不足、注意力难以集中、身体机能下降）。高精氨酸（hArg）是一种非蛋白质氨基酸，可能会增加一氧化氮（NO）的可用性。NO控制血管舒张、血流量、线粒体呼吸并改善身体机能。因此，AMI后血浆hArg水平较低可能会影响与身体机能相关的早期抑郁症状。这项纵向研究旨在确定AMI后即刻、第四天和6个月时血浆hArg浓度的变化过程，并研究hArg与早期抑郁症状之间的关联。如在AMI后第四天观察到的，AMI患者中hArg水平的降低与性别、年龄、体重指数和AMI类型无关。六个月后，hArg浓度与基线值不再有显著差异。与男性相比，女性在AMI后不久以及第四天时的hArg浓度较低。在AMI后的最初几天内，汉密尔顿抑郁量表（HAMD-17）和贝克抑郁量表第二版（BDI-II）的总抑郁评分以及与身体机能相关的早期抑郁症状，如精力不足、注意力难以集中和身体机能下降，都与低hArg浓度相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ad/11718095/47eb92b3991a/41598_2024_84930_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ad/11718095/ac6654d1c95d/41598_2024_84930_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ad/11718095/340aab15fb9f/41598_2024_84930_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ad/11718095/f3140d171d1a/41598_2024_84930_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ad/11718095/47eb92b3991a/41598_2024_84930_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ad/11718095/ac6654d1c95d/41598_2024_84930_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ad/11718095/340aab15fb9f/41598_2024_84930_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ad/11718095/f3140d171d1a/41598_2024_84930_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ad/11718095/47eb92b3991a/41598_2024_84930_Fig4_HTML.jpg

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本文引用的文献

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Antioxidants (Basel). 2022 Oct 22;11(11):2083. doi: 10.3390/antiox11112083.
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Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure.精氨酸和肌酸缺乏不会加重小鼠缺血性心力衰竭。
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The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function.
精氨酸抑制 T 细胞功能调节动脉粥样硬化形成。
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Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice.心血管相关 microRNAs 的表达在 L-精氨酸：甘氨酸 amidinotransferase 缺陷型小鼠中发生改变。
Sci Rep. 2022 Mar 24;12(1):5108. doi: 10.1038/s41598-022-08846-1.
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Assessment of trimethylamine N-oxide (TMAO) as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder (PTSD) after acute myocardial infarction.评估三甲胺 N-氧化物（TMAO）作为急性心肌梗死后易发生创伤后应激障碍（PTSD）患者严重应激的潜在生物标志物。
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