高血压患者衰弱综合征与生活质量的关系：多维分析
The relationship between frailty syndrome and quality of life in patients with hypertension: a multidimensional analysis.
作者信息
Uchmanowicz Bartosz, Chudiak Anna, Gobbens Robbert, Kubielas Grzegorz, Godek Piotr, Surma Stanisław, Bednarska-Chabowska Dorota, Uchmanowicz Izabella, Czapla Michał
机构信息
Department of Nursing, Faculty of Nursing and Midwifery, Wroclaw Medical University, Wroclaw, 51-618, Poland.
Zonnehuisgroep Amstelland, Amstelveen, The Netherlands.
出版信息
BMC Geriatr. 2025 Jan 9;25(1):23. doi: 10.1186/s12877-024-05669-9.
BACKGROUND
Hypertension is a common condition among the elderly and is frequently accompanied by frailty syndrome (FS). The coexistence of hypertension and FS poses significant challenges in patient management and negatively impacts the quality of life (QoL). This study aimed to analyze the relationship between FS and QoL in elderly patients with suspected hypertension.
METHODS
A cross-sectional study was conducted involving 201 patients aged 65 years or older, referred to a Hypertension Clinic for diagnostic evaluation. Frailty was assessed using the Tilburg Frailty Indicator (TFI), and QoL was evaluated with the World Health Organization Quality of Life Instrument (WHOQOL-BREF). Sociodemographic and clinical data were collected, and statistical analyses were performed to identify correlations between FS and QoL.
RESULTS
The study found that 79.60% of the patients were identified as frail (TFI ≥ 5). FS was significantly negatively correlated with all domains of QoL, including physical health (r = -0.634, p < 0.001), psychological health (r = -0.675, p < 0.001), social relationships (r = -0.528, p < 0.001), and environmental factors (r = -0.626, p < 0.001). Multivariate analysis revealed that physical (β = -0.091, p < 0.001) and psychological components of FS (β = -0.128, p = 0.016), as well as age (β = -0.022, p = 0.004), were significant predictors of lower QoL scores. Loneliness (β = -0.235, p = 0.049) was also a significant predictor of lower QoL.
CONCLUSIONS
The study demonstrated a strong association between FS and reduced QoL in elderly hypertensive patients, emphasizing the need for comprehensive assessments and personalized management strategies. Routine evaluation of frailty and the implementation of targeted interventions aimed at improving physical, psychological, and social well-being could substantially enhance QoL in this vulnerable population.
CLINICAL TRIAL NUMBER
Not applicable.
背景
高血压在老年人中很常见，且常伴有衰弱综合征（FS）。高血压与FS并存给患者管理带来了重大挑战，并对生活质量（QoL）产生负面影响。本研究旨在分析疑似高血压老年患者中FS与QoL之间的关系。
方法
进行了一项横断面研究，纳入了201名65岁及以上转诊至高血压诊所进行诊断评估的患者。使用蒂尔堡衰弱指标（TFI）评估衰弱情况，并用世界卫生组织生活质量量表（WHOQOL-BREF）评估QoL。收集了社会人口学和临床数据，并进行统计分析以确定FS与QoL之间的相关性。
结果
研究发现79.60%的患者被认定为衰弱（TFI≥5）。FS与QoL的所有领域均呈显著负相关，包括身体健康（r = -0.634，p < 0.001）、心理健康（r = -0.675，p < 0.001）、社会关系（r = -0.528，p < 0.001）和环境因素（r = -0.626，p < 0.001）。多变量分析显示，FS的身体（β = -0.091，p < 0.001）和心理成分（β = -0.128，p = 0.016）以及年龄（β = -0.022，p = 0.004）是QoL得分较低的显著预测因素。孤独感（β = -0.235，p = 0.049）也是QoL较低的显著预测因素。
结论
该研究表明老年高血压患者中FS与QoL降低之间存在密切关联，强调了进行全面评估和个性化管理策略的必要性。对衰弱进行常规评估并实施旨在改善身体、心理和社会福祉的针对性干预措施，可大幅提高这一弱势群体的QoL。
临床试验编号
不适用。
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