Sharma Abhishek, Sharma Nidhi, Singh Rahul K, Chahal Aksh
Department of Physiotherapy, Arogyam Institute of Paramedical and Allied Sciences (Affiliated to H.N.B. Uttarakhand Medical Education University), Roorkee, Uttarakhand, India.
Department of Health Science, Uttaranchal College of Health Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.
Indian J Psychiatry. 2024 Nov;66(11):997-1013. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_735_23. Epub 2024 Nov 16.
Schizophrenia is considered to be a condition that usually manifests at any age but commonly seen in young people and is associated with a genetic propensity in brain development.
The study explores the impact of aerobic training on brain architecture, hippocampal volume, cardiorespiratory parameters, and quality of life in young individuals with schizophrenia. The investigation focuses on the correlation between genetic predisposition, hippocampal atrophy, and diminished cardiorespiratory fitness, aiming to discern potential benefits of aerobic exercise on both physical and mental health outcomes.
A systematic search was conducted in major online databases, such as Cochrane, Embase, PEDro, Web of science and PubMed (Medline). Two authors independently evaluated possibilities of bias, retrieved data and decided which trials should be included in the analysis. Total of 13 published articles (randomized clinical and controlled trials) with 656 patients was included from January 2010 to December 2020.
Following aerobic exercise training, people with schizophrenia presented with an increased hippocampus volume and enhanced cardiorespiratory endurance ( ˂0.05). Due to a lack of information, we rated the majority of the studies' risk of bias in relation to random sequence creation, allocation concealment, and selective reporting as uncertain.
Findings from the present review propose aerobic exercise program as a meaningful therapeutic intervention for schizophrenia patients in terms of maintaining appropriate brain architecture, increasing the hippocampal volume, improving cardiorespiratory parameters and health related quality of life.
精神分裂症被认为是一种通常在任何年龄都可能出现，但常见于年轻人的疾病，且与大脑发育的遗传倾向有关。
本研究探讨有氧运动训练对患有精神分裂症的年轻人的脑结构、海马体体积、心肺参数和生活质量的影响。该调查重点关注遗传易感性、海马体萎缩和心肺功能下降之间的相关性，旨在识别有氧运动对身心健康结果的潜在益处。
在主要在线数据库，如Cochrane、Embase、PEDro、科学网和PubMed（Medline）中进行了系统检索。两位作者独立评估偏倚可能性、检索数据并决定哪些试验应纳入分析。从2010年1月至2020年12月共纳入13篇已发表文章（随机临床和对照试验），涉及656名患者。
经过有氧运动训练后，精神分裂症患者的海马体体积增加，心肺耐力增强（˂0.05）。由于信息不足，我们将大多数研究在随机序列生成、分配隐藏和选择性报告方面的偏倚风险评定为不确定。
本综述的结果表明，有氧运动计划对于精神分裂症患者来说是一种有意义的治疗干预措施，有助于维持适当的脑结构、增加海马体体积、改善心肺参数和与健康相关的生活质量。
