Zhou Chaoyu, Wu Haiyan, Zhang Lei, Xiao Xiao, Wang Xiaodan, Li Mingju, Cai Runqiu, You Jia, Chen Qi, Yang Yifei, Tian Xinyuan, Bai Qianyu, Chen Yinzhu, Bao Huihui, Liu Tianlong
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Chinese Academy of Medical Science Research Unit, NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, China.
Nanomaterials (Basel). 2025 Jan 4;15(1):69. doi: 10.3390/nano15010069.
Microplastics, defined as plastic fragments smaller than 5 mm, degrade from larger pollutants, with nanoscale microplastic particles presenting significant biological interactions. This study investigates the toxic effects of polystyrene nanoplastics (PS-NPs) on juvenile mice, which were exposed through lactation milk and drinking water at concentrations of 0.01 mg/mL, 0.1 mg/mL, and 1 mg/mL. The results show that PS-NP exposure during lactation and juvenile periods caused delayed weight gain and impaired organ development, particularly in the liver and kidneys, without causing functional abnormalities or toxic injuries. The primary toxicity of PS-NPs was observed in the intestinal tract, including shortened villi, disrupted tight junctions, inhibited epithelial cell proliferation, and oxidative stress responses. These findings highlight the importance of evaluating the developmental toxicity of nanoplastics at environmentally relevant doses.
微塑料被定义为尺寸小于5毫米的塑料碎片，由较大的污染物降解而来，纳米级微塑料颗粒具有显著的生物相互作用。本研究调查了聚苯乙烯纳米塑料（PS-NPs）对幼鼠的毒性作用，幼鼠通过哺乳期乳汁和饮用水分别以0.01毫克/毫升、0.1毫克/毫升和1毫克/毫升的浓度接触PS-NPs。结果表明，在哺乳期和幼年期接触PS-NPs会导致体重增加延迟和器官发育受损，尤其是肝脏和肾脏，且未引起功能异常或毒性损伤。PS-NPs的主要毒性作用发生在肠道，包括绒毛缩短、紧密连接破坏、上皮细胞增殖受抑制以及氧化应激反应。这些发现凸显了在环境相关剂量下评估纳米塑料发育毒性的重要性。
