AIM: The aim of the present study was to comparatively evaluate the retention of complete dentures and oral health-related quality of life (OHRQoL) of patients with conventional and bioelectric impressions or transcutaneous electric nerve stimulation (TENS). MATERIALS AND METHODS: A total of thirty (n = 30) completely edentulous patients were randomly distributed into two groups: Group-C (n = 15) (Conventional) and Group-T (n = 15) (bioelectric). In Group C, border molding was performed using the manual manipulation of borders, and the final impression was made using zinc-oxide eugenol. In Group T, border molding and final impression were performed with the TENS application. Dentures were fabricated, and retention was evaluated with a digital gauge. OHRQoL was assessed at insertion and after three months of follow-up using the Oral Health Impact Profile Edentulous in Hindi (OHIP-Edent-H) questionnaire. A two-way ANOVA test was used for the significance level ( < 0.05). Student t-test was used for intergroup comparison, and paired -test was used for intragroup comparison of OHRQoL. RESULTS: There was no significant difference in the retention of maxillary and mandibular dentures fabricated with both techniques ( = 0.283,  = 0.682). Although, OHRQoL increased significantly in both groups at follow-up ( = 0.001). However, at follow-up, the Functional Limitation (FL) domain was significantly better in the conventional group. CONCLUSIONS: Although, there was no significant difference in retention and OHRQoL between both groups. However, more clinical trials with large samples and longer follow-ups are required to reach a conclusive result.