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[组织形态学定义的肾细胞癌2025:当前世界卫生组织分类及未来新兴亚型]

[Histomorphologically defined renal cell carcinomas 2025 : Current WHO classification and emerging future subtypes].

作者信息

Stöhr C, Fiegl A, Bercebal C, Agaimy A, Hartmann A

机构信息

Institut für Pathologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 8-10, 91054, Erlangen, Deutschland.

Comprehensive Cancer Center EMN, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Deutschland.

出版信息

Pathologie (Heidelb). 2025 Feb;46(1):13-20. doi: 10.1007/s00292-024-01406-6. Epub 2025 Jan 16.

DOI:10.1007/s00292-024-01406-6
PMID:39821464
Abstract

BACKGROUND

The latest edition of the WHO classification of urinary and male genital tumours was published in 2022. The revision was based on the newest scientific literature. This article summarizes the updated recommendations regarding the classification of histomorphologically defined tumours.

RESULTS AND CONCLUSIONS

The current edition of the WHO classification made some adjustments on the classification of histomorphologically defined tumour types. Papillary renal cell carcinoma is no longer categorized into two subtypes. Also, the new classification recognized the benign nature of clear cell papillary tumours, which are no longer regarded as carcinomas. Finally, several emerging renal tumours were introduced.

摘要

背景

世界卫生组织(WHO)泌尿及男性生殖系统肿瘤的最新分类于2022年发布。此次修订基于最新的科学文献。本文总结了关于组织形态学定义肿瘤分类的更新建议。

结果与结论

WHO分类的当前版本对组织形态学定义的肿瘤类型分类进行了一些调整。乳头状肾细胞癌不再分为两个亚型。此外,新分类认可了透明细胞乳头状肿瘤的良性性质,这类肿瘤不再被视为癌。最后,引入了几种新出现的肾肿瘤。

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1
[Histomorphologically defined renal cell carcinomas 2025 : Current WHO classification and emerging future subtypes].[组织形态学定义的肾细胞癌2025:当前世界卫生组织分类及未来新兴亚型]
Pathologie (Heidelb). 2025 Feb;46(1):13-20. doi: 10.1007/s00292-024-01406-6. Epub 2025 Jan 16.
2
[Molecularly defined renal cell carcinomas].[分子定义的肾细胞癌]
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The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.《2016 年世界卫生组织泌尿系统及男性生殖器官肿瘤分类—第 A 部分:肾脏、阴茎和睾丸肿瘤》。
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[2022 WHO classification of renal cell carcinomas: Focus on papillary renal cell carcinoma].[2022年世界卫生组织肾细胞癌分类:聚焦于乳头状肾细胞癌]
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The Tumor Entity Denominated "clear cell-papillary renal cell carcinoma" According to the WHO 2016 new Classification, have the Clinical Characters of a Renal Cell Adenoma as does Harbor a Benign Outcome.根据世界卫生组织2016年新分类法命名为“透明细胞乳头状肾细胞癌”的肿瘤实体,具有肾细胞腺瘤的临床特征,预后良好。
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The Heidelberg classification of renal cell tumours.肾细胞肿瘤的海德堡分类
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The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.2022 年世界卫生组织泌尿系统和男性生殖器官肿瘤分类 - 第 A 部分:肾脏、阴茎和睾丸肿瘤。
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Clear cell papillary renal cell carcinoma, renal angiomyoadenomatous tumor, and renal cell carcinoma with leiomyomatous stroma relationship of 3 types of renal tumors: a review.透明细胞乳头状肾细胞癌、肾血管肌腺瘤和富含平滑肌的肾细胞癌 3 种肾肿瘤的关系:综述。
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Papillary or pseudopapillary tumors of the kidney.肾乳头状或假乳头状肿瘤。
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本文引用的文献

1
Updates in Grading of Renal Cell Carcinomas Beyond Clear Cell Renal Cell Carcinoma and Papillary Renal Cell Carcinoma.除透明细胞肾细胞癌和乳头状肾细胞癌以外的肾细胞癌分级的更新。
Adv Anat Pathol. 2022 May 1;29(3):117-130. doi: 10.1097/PAP.0000000000000341.
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Acquired Cystic Kidney Disease-associated Renal Cell Carcinoma (ACKD-RCC) Harbor Recurrent Mutations in KMT2C and TSC2 Genes.获得性囊性肾病相关性肾细胞癌(ACKD-RCC)携带 KMT2C 和 TSC2 基因的复发性突变。
Am J Surg Pathol. 2020 Nov;44(11):1479-1486. doi: 10.1097/PAS.0000000000001530.
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Long-Term Outcomes of Patients With Low Grade Cystic Renal Epithelial Neoplasms.
低级别囊性肾上皮性肿瘤患者的长期预后。
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Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Harbor TSC Mutations: Molecular Analysis Supports an Expanding Clinicopathologic Spectrum.嗜酸性实体和囊性(ESC)肾细胞癌存在 TSC 突变:分子分析支持扩展的临床病理谱。
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The ISUP system of staging, grading and classification of renal cell neoplasia.肾细胞肿瘤的国际泌尿病理学会(ISUP)分期、分级及分类系统
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Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution.具有透明细胞肾细胞癌和透明细胞乳头状肾细胞癌重叠特征的肾肿瘤:来自单一机构的37例临床病理研究
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Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity.理解肾细胞癌的病理变异:从生物学复杂性中提炼治疗机会。
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Collecting duct carcinomas represent a unique tumor entity based on genetic alterations.收集管癌代表了一种基于遗传改变的独特肿瘤实体。
PLoS One. 2013 Oct 22;8(10):e78137. doi: 10.1371/journal.pone.0078137. eCollection 2013.
10
Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features.再次探讨肾嗜酸细胞瘤:109 例病例的临床病理研究,重点关注有问题的诊断特征。
Histopathology. 2010 Dec;57(6):893-906. doi: 10.1111/j.1365-2559.2010.03726.x.