Saadh Mohamed J, Allela Omer Qutaiba B, Kareem Radhwan Abdul, Sanghvi Gaurav, Menon Soumya V, Sharma Pawan, Tomar Balvir S, Sharma Aanchal, Sameer Hayder Naji, Hamad Atheer Khdyair, Athab Zainab H, Adil Mohaned
Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
College of Pharmacy, Alnoor University, Nineveh, Iraq.
Neuromolecular Med. 2025 Jan 16;27(1):10. doi: 10.1007/s12017-025-08830-8.
The primary source of short-chain fatty acids (SCFAs), now recognized as critical mediators of host health, particularly in the context of neurobiology and cancer development, is the gut microbiota's fermentation of dietary fibers. Recent research highlights the complex influence of SCFAs, such as acetate, propionate, and butyrate, on brain cancer progression. These SCFAs impact immune modulation and the tumor microenvironment, particularly in brain tumors like glioma. They play a critical role in regulating cellular processes, including apoptosis, cell differentiation, and inflammation. Moreover, studies have linked SCFAs to maintaining the integrity of the blood-brain barrier (BBB), suggesting a protective role in preventing tumor infiltration and enhancing anti-tumor immunity. As our understanding of the gut-brain axis deepens, it becomes increasingly important to investigate SCFAs' therapeutic potential in brain cancer management. Looking into how SCFAs affect brain tumor cells and the environment around them could lead to new ways to prevent and treat these diseases, which could lead to better outcomes for people who are dealing with these challenging cancers.
短链脂肪酸（SCFAs）的主要来源是肠道微生物群对膳食纤维的发酵，SCFAs现在被认为是宿主健康的关键介质，尤其是在神经生物学和癌症发展的背景下。最近的研究强调了乙酸盐、丙酸盐和丁酸盐等SCFAs对脑癌进展的复杂影响。这些SCFAs影响免疫调节和肿瘤微环境，特别是在胶质瘤等脑肿瘤中。它们在调节细胞过程中起关键作用，包括细胞凋亡、细胞分化和炎症。此外，研究已将SCFAs与维持血脑屏障（BBB）的完整性联系起来，表明其在防止肿瘤浸润和增强抗肿瘤免疫力方面具有保护作用。随着我们对肠-脑轴的理解不断深入，研究SCFAs在脑癌治疗中的潜在作用变得越来越重要。研究SCFAs如何影响脑肿瘤细胞及其周围环境可能会带来预防和治疗这些疾病的新方法，从而为患有这些具有挑战性癌症的患者带来更好的治疗效果。
