针刀疗法联合中药治疗膝骨关节炎的Meta分析

Needle knife therapy combined with chinese herbal medicine in the treatment of knee osteoarthritis: a meta-analysis.

作者信息

Peng Qinglin, Han Jie, Wu Ruiqi, Wu Yukun, Chen Feng, Lai Yu

机构信息

Graduate School, Guangxi University of Chinese Medicine Nanning 530000, Guangxi Zhuang Autonomous Region, China.

Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530000, Guangxi Zhuang Autonomous Region, China.

出版信息

Am J Transl Res. 2024 Dec 15;16(12):7238-7247. doi: 10.62347/VGCJ2742. eCollection 2024.

DOI:10.62347/VGCJ2742

PMID:39822562

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11733337/

Abstract

OBJECTIVE

To systematically evaluate the effectiveness of the combined Needle Knife Therapy (NKT) and Chinese Herbal Medicine (CHM) treatment for knee osteoarthritis (KOA) and to provide clinical evidence supporting its application in managing the condition.

METHODS

Relevant articles were retrieved from PubMed, Medline, Embase, Wanfang, and China National Knowledge Network (CNKI) from the inception of the databases up to February 18, 2023. Randomized controlled trials (RCTs) on the efficacy of NKT combined with CHM were appraised for inclusion. The meta-analysis was conducted using RevMan 5.3 and was registered with the International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY) (202470051).

RESULTS

A total of 11 RCTs involving 880 patients were included. The meta-analysis showed that the combined therapy was superior to NKT alone in the treatment of KOA [relative risk (RR) = 1.09; 95% confidence interval (CI): (1.03, 1.14); P = 0.002]. The combined therapy showed a significant reduction in the Visual Analog Scale (VAS) score [RR = -0.98; 95% CI: -1.12, -0.84; P < 0.00001] and symptom scores [RR = -1.75; 95% CI: (-1.87, -1.63); P < 0.00001] compared to single NT therapy. There was no significant difference in the Traditional Chinese Medicine (TCM) syndrome scores between the two groups [RR = -0.23; 95% CI: (-0.56, 0.10); = 0.18]. Furthermore, we observed a marked increase in lysholmy scores in the combination group than in the control group [RR = -1.04; 95% CI: (-1.31, -0.77); < 0.00001].

CONCLUSIONS

The combination of needle-knife therapy and Chinese herbal medicine exhibits promising clinical efficacy in the treatment of KOA.

摘要

目的

系统评价针刀疗法（NKT）联合中药（CHM）治疗膝骨关节炎（KOA）的有效性，为其临床应用提供依据。

方法

从PubMed、Medline、Embase、万方和中国知网（CNKI）数据库建库至2023年2月18日检索相关文献。纳入评估NKT联合CHM疗效的随机对照试验（RCT）。使用RevMan 5.3进行荟萃分析，并在国际注册系统评价和荟萃分析方案平台（INPLASY）（202470051）注册。

结果

共纳入11项RCT，涉及880例患者。荟萃分析显示，联合治疗在KOA治疗中优于单纯NKT治疗[相对危险度（RR）=1.09；95%置信区间（CI）：（1.03，1.14）；P=0.002]。与单纯NKT治疗相比，联合治疗的视觉模拟量表（VAS）评分[RR=-0.98；95%CI：-1.12，-0.84；P<0.00001]和症状评分[RR=-1.75；95%CI：（-1.87，-1.63）；P<0.00001]显著降低。两组中医证候评分无显著差异[RR=-0.23；95%CI：（-0.56，0.10）；P=0.18]。此外，我们观察到联合组的lysholmy评分比对照组显著增加[RR=-1.04；95%CI：（-1.31，-0.77）；P<0.00001]。