Gilsbach Susanne, Leuchtenberger Julia, Herpertz-Dahlmann Beate, Voderholzer Ulrich, Konrad Kerstin, von Polier Georg, Seitz Jochen, Fichter Manfred
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Schoen Clinic Roseneck, Prien, Germany.
Eat Weight Disord. 2025 Jan 18;30(1):7. doi: 10.1007/s40519-025-01713-8.
BACKGROUND: Bulimia nervosa (BN) is a serious mental illness with impulsivity as a cardinal symptom. Impulsivity contributes to various other, often comorbid, mental disorders, such as attention deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD). The aim of this study was to explore comorbidities of BN with ADHD and BPD as well as the contribution of impulsivity as an underlying trait linking these disorders. METHODS: Hundred and fifteen females with BN and 98 healthy matched controls (HC) (age range between 16 and 48 years) were assessed regarding adult and childhood-ADHD, personality disorders and impulsivity. RESULTS: Patients with BN were more impulsive (p < 0.001) and more often fulfilled criteria of childhood/adulthood ADHD (p < 0.001) than HC, and criteria of BPD than expected in the general population. Childhood-ADHD (p = 0.009) and BPD (p = 0.017) both were significant positive predictors for impulsivity scores found in patients with BN. CONCLUSION: Comorbidity with ADHD and BPD often is prevalent in BN and associated with an increase in impulsivity, the latter being a relevant transdiagnostic trait. It might be beneficial to explore impulsivity as well as comorbidities in the clinical care of patients with BN. LEVEL OF EVIDENCE III: Evidence obtained from well-designed cohort or case-control analytic studies.
背景:神经性贪食症(BN)是一种严重的精神疾病,冲动是其主要症状。冲动会导致各种其他通常共病的精神障碍,如注意力缺陷多动障碍(ADHD)和边缘性人格障碍(BPD)。本研究的目的是探讨BN与ADHD和BPD的共病情况,以及冲动作为联系这些障碍的潜在特质所起的作用。 方法:对115名患有BN的女性和98名健康匹配对照(HC)(年龄在16至48岁之间)进行了成人及儿童期ADHD、人格障碍和冲动性评估。 结果:与HC相比,BN患者更冲动(p < 0.001),更常符合儿童期/成人期ADHD的标准(p < 0.001),且符合BPD标准的情况比一般人群预期的更常见。儿童期ADHD(p = 0.009)和BPD(p = 0.017)均是BN患者冲动性得分的显著正向预测因素。 结论:BN患者中ADHD和BPD的共病情况通常很普遍,且与冲动性增加有关,后者是一种相关的跨诊断特质。在BN患者的临床护理中探索冲动性以及共病情况可能会有所帮助。 证据水平III:从设计良好的队列或病例对照分析研究中获得的证据。
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