Zhang Yudi, Zhu Siqiang, Liu Zhaodong, Hu Yonghao, Zhang Yongjian, Shang Liang, Li Leping
Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Department of Gastrointestinal Surgery, Medical Science and Technology Innovation Center, Shandong First Medical University , Jinan, 250021, Shandong, China.
Discov Oncol. 2025 Jan 21;16(1):68. doi: 10.1007/s12672-025-01808-9.
Aging is an inevitable physiological process in organisms, and the development of tumors is closely associated with cellular senescence. This article initially examines the role of cellular senescence in tumorigenesis, emphasizing the correlation between telomere length-a marker of cellular senescence-and tumor risk. Concurrently, the study explores the expression levels of senescence-associated markers, such as p16, p53, and mTOR, in the context of tumor development. Additionally, the study investigates the impact of tumors on cellular and organismal senescence, including the effects on immune system function and metabolic processes. Ultimately, the discussion explores the potential application of anti-aging strategies in tumor therapy and considers the possibility of utilizing senescence mechanisms as a novel therapeutic approach for tumors. This research provides novel insights into the complex interplay between senescence and tumor development, suggesting potential strategies for future preventative measures and therapeutic interventions.
衰老是生物体不可避免的生理过程，肿瘤的发生与细胞衰老密切相关。本文首先探讨细胞衰老在肿瘤发生中的作用，强调作为细胞衰老标志物的端粒长度与肿瘤风险之间的相关性。同时，该研究在肿瘤发展的背景下，探究衰老相关标志物如p16、p53和mTOR的表达水平。此外，该研究还调查了肿瘤对细胞和机体衰老的影响，包括对免疫系统功能和代谢过程的影响。最终，讨论探讨了抗衰老策略在肿瘤治疗中的潜在应用，并考虑利用衰老机制作为肿瘤新治疗方法的可能性。这项研究为衰老与肿瘤发展之间的复杂相互作用提供了新的见解，为未来的预防措施和治疗干预提出了潜在策略。
