Chechko Natalia, Nehls Susanne
Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Aachen, Germany.
Institute of Neuroscience and Medicine, JARA-Institute Brain Structure Function Relationship (INM 10), Research Center Jülich, Jülich, Germany.
Neurosci Insights. 2025 Jan 19;20:26331055251315488. doi: 10.1177/26331055251315488. eCollection 2025.
The postpartum period is marked by radical changes in the maternal brain. Seeking to explore the mechanisms that underlie these changes, this article focuses on the relevant hormonal, inflammatory, and behavioral factors. Longitudinal imaging studies have shed valuable light on both short- and long-term alterations in postpartum brain structure and connectivity, particularly in the regions that play key roles in emotion regulation and stress response. It is plausible that these peripartum changes contribute to the mental health challenges new mothers face, including postpartum depression. Adding to our understanding of postpartum neurobiology, this insight highlights the importance of personalized intervention in the promotion of maternal well-being.
产后时期的特点是产妇大脑发生根本性变化。为了探索这些变化背后的机制，本文重点关注相关的激素、炎症和行为因素。纵向成像研究为产后大脑结构和连通性的短期和长期变化提供了宝贵的见解，特别是在情绪调节和应激反应中起关键作用的区域。这些围产期变化可能导致新妈妈面临的心理健康挑战，包括产后抑郁症。这一见解加深了我们对产后神经生物学的理解，强调了个性化干预对促进产妇福祉的重要性。
