Wang Ke, Xu Yan, Qin Ningxin, Guo Yi, Bai Jie, Li Zheyuan
Center of Reproductive Medicine, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
Department of Nursing, Shanghai Sanda University, Shanghai, 201209, People's Republic of China.
J Multidiscip Healthc. 2025 Jan 14;18:123-132. doi: 10.2147/JMDH.S494319. eCollection 2025.
To explore the effects of donor sperm on reproductive quality of life, sleep quality and erectile function in patients with severe oligoasthenospermia after the failure of intracytoplasmic sperm injection (ICSI), and to provide targeted reference for intervention.
From January 2021 to December 2023, patients with severe oligoasthenospermia who received assisted pregnancy treatment in Obstetrics and Gynecology Hospital Affiliated to Tongji University were selected as the study objects. Among them, 82 cases using sperm donor assisted pregnancy after ICSI failure were set as the observation group, and 82 cases using propensity score 1:1 matching ICSI failure after ICSI assisted pregnancy were set as the control group. The levels of serum total testosterone, reproductive quality of life, sleep quality and erectile function of the two groups were compared using the general data questionnaire, FertiQoL, Pittsburgh Sleep Quality Index (PSQI) and International erectile Function Index -5(IIEF-5).
There was no significant difference in social demographic data and serum total testosterone level between the two groups after matching propensity score (>0.05). The total score of FertiQoL and PSQI in the observation group were higher than those in the control group, and the incidence of erectile dysfunction was higher than that in the control group, with statistical significance (<0.05).
The use of donor sperm for pregnancy after ICSI failure in patients with severe oligoasthenospermia has a great impact on their reproductive life, sleep quality and erectile function. Medical staff should pay attention to the quality of life and erectile function of these patients, and formulate targeted measures to help these patients cope positively.
探讨供精对严重少弱精子症患者卵胞浆内单精子注射（ICSI）失败后生殖生活质量、睡眠质量及勃起功能的影响，为干预提供针对性参考。
选取2021年1月至2023年12月在同济大学附属第一妇婴保健院接受辅助妊娠治疗的严重少弱精子症患者为研究对象。其中，将82例ICSI失败后采用供精辅助妊娠的患者设为观察组，将82例采用倾向得分1:1匹配的ICSI失败后ICSI辅助妊娠的患者设为对照组。采用一般资料问卷、FertiQoL、匹兹堡睡眠质量指数（PSQI）及国际勃起功能指数-5（IIEF-5）比较两组患者的血清总睾酮水平、生殖生活质量、睡眠质量及勃起功能。
倾向得分匹配后两组社会人口学资料及血清总睾酮水平比较，差异无统计学意义（>0.05）。观察组FertiQoL及PSQI总分高于对照组，勃起功能障碍发生率高于对照组，差异有统计学意义（<0.05）。
严重少弱精子症患者ICSI失败后采用供精妊娠对其生殖生活、睡眠质量及勃起功能有较大影响。医护人员应关注这些患者的生活质量及勃起功能，制定针对性措施帮助这些患者积极应对。
